轉化生長因子-α

轉化生長因子-α
轉化生長因子-α
	PDB rendering based on 1mox.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1GK5, 1MOX, 1YUF, 1YUG, 2TGF, 3E50, 3TGF, 4TGF
標識
代號	TGFA; TFGA
擴展標識	遺傳學：190170 鼠基因：98724 同源基因：2431 GeneCards: TGFA Gene
基因本體論描述
分子功能	· glycoprotein binding; · MAP kinase kinase activity; · epidermal growth factor receptor binding; · protein binding; · growth factor activity;
細胞成分	· extracellular space; · nucleus; · plasma membrane; · cell surface; · integral to membrane; · basolateral plasma membrane; · cytoplasmic vesicle; · perinuclear region of cytoplasm;
生物過程	· MAPK cascade; · activation of MAPK activity; · angiogenesis; · epidermal growth factor receptor signaling pathway; · cell proliferation; · wound healing; · response to drug; · negative regulation of apoptotic process; · positive regulation of epidermal growth factor-activated receptor activity; · positive regulation of mitosis; · positive regulation of epithelial cell proliferation; · positive regulation of cell division; · mammary gland alveolus development;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	7039
Ensembl	ENSG00000163235
UniProt	P01135
mRNA序列	NM_001099691
蛋白序列	NP_001093161
基因位置	Chr 2:; 70.67 – 70.78 Mb
PubMed查詢	[1]
	閱; 論; 編;

轉化生長因子-α（英語：Transforming growth factor - α，簡稱TGF-α）是一小分子的多肽。可以誘導上皮發育，可以使多種細胞轉化。與表皮生長因子的胺基酸順序相似。在某些人類癌症中有上調。轉化生長因子-α是由巨噬細胞,腦細胞和表皮細胞產生的。

與表皮生長因子類似，轉化生長因子-α通過與細胞表面的受體表皮生長因子受體(EGFR)結合而起作用。^[1]^[2]與表皮生長因子受體的高親和力結合，激發受體內在的酪氨酸激酶的活性，從而啟動了信號傳導級聯而導致多種生物化學變化，細胞內鈣水平上升, 增加糖酵解與蛋白質合成, 增加某些基因(包括表皮生長因子受體)的表達, 最終導致DNA合成和細胞增殖。

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參考文獻

^ Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5
^ Kramer, A.; Yang, F.-C.; Snodgrass, P.; Li, X.; Scammell, T. E.; Davis, F. C.; Weitz, C. J. : Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294: 2511-2515, 2001.

外部連結

[1] Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

[2] Kramer, A.; Yang, F.-C.; Snodgrass, P.; Li, X.; Scammell, T. E.; Davis, F. C.; Weitz, C. J. : Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294: 2511-2515, 2001.

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