2-乙基-2-苯基丙二醯胺

化合物

2-乙基-2-苯基丙二醯胺苯基乙基丙二醯胺(英語:Phenylethylmalonamide;簡稱PEMA)是抗驚厥藥物撲米酮活性代謝物[1]儘管它的產生濃度比另一種活性代謝物苯巴比妥低得多。[2]

2-乙基-2-苯基丙二醯胺
IUPAC名
2-Ethyl-2-phenylpropanediamide
識別
CAS號 7206-76-0  checkY
PubChem 23611
ChemSpider 22078
SMILES
 
  • CCC(c1ccccc1)(C(=O)N)C(=O)N
InChI
 
  • 1/C11H14N2O2/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15)
InChIKey JFZHPFOXAAIUMB-UHFFFAOYAN
性質
化學式 C11H14N2O2
摩爾質量 206.24 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考資料

編輯
  1. ^ Baumel, I. P.; Gallagher, B. B.; Mattson, R. H. Phenylethylmalonamide (PEMA). An important metabolite of primidone. Archives of Neurology. 1972-07, 27 (1) [2024-03-21]. ISSN 0003-9942. PMID 4626105. doi:10.1001/archneur.1972.00490130036005. (原始內容存檔於2024-03-21). 
  2. ^ El-Masri HA, Portier CJ. Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice. Drug Metab. Dispos. June 1998, 26 (6): 585–94. PMID 9616196.