整聯蛋白β-1(英語:Integrin beta-1),也被稱為 CD29 是一個由人類基因 ITGB1 編碼的蛋白質[5]。CD29是整合素極晚期抗原受體的一個亞基。它與α-3亞基形成整合素α3β1,作為神經生長因子1絡絲蛋白的受體。在心肌骨骼肌種,整聯蛋白β-1會選擇性表現為β-1D蛋白質異形體。

CD29
已知的結構
PDB直系同源搜尋: PDBe RCSB
識別號
別名ITGB1;, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
外部IDOMIM135630 MGI96610 HomoloGene22999 GeneCardsITGB1
基因位置(人類
10號染色體
染色體10號染色體[1]
10號染色體
CD29的基因位置
CD29的基因位置
基因座10p11.22起始32,900,319 bp[1]
終止33,005,792 bp[1]
RNA表現模式
查閱更多表現資料
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_010578

蛋白序列

NP_002202
​NP_391988
​NP_596867

NP_034708

基因位置​(UCSC)Chr 10: 32.9 – 33.01 MbChr 8: 129.41 – 129.46 Mb
PubMed​查找[3][4]
維基資料
檢視/編輯人類檢視/編輯小鼠

相互作用

編輯

CD29已經顯示出與下列蛋白質交互作用

參考文獻

編輯
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
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  6. ^ Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721. 
  7. ^ Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808. 
  8. ^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. 
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  10. ^ 10.0 10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7. 
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  15. ^ 15.0 15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842. 
  16. ^ Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379. 
  17. ^ Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149. 
  18. ^ Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200. 
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  24. ^ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0. 
  25. ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181. 
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外部連結

編輯