CYP27B1

calcidiol 1-monooxygenase
命名
系統命名
縮寫
識別碼
EC編號	1.14.15.18
CAS號	9081-36-1
資料庫
IntEnz	IntEnz瀏覽
BRENDA（英語：BRENDA）	BRENDA入口
ExPASy（英語：ExPASy）	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc（英語：MetaCyc）	代謝路徑
PRIAM（英語：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本體	AmiGO / EGO
搜尋
PMC	相關文獻
PubMed	相關文獻

25-羥基維生素D3 1-α-羥化酶
識別號
別名	CYP27B1；, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1
外部ID	OMIM：609506 MGI：1098274 HomoloGene：37139 GeneCards：CYP27B1
EC number	1.14.15.18
相關疾病
	1-alpha-hydroxylase deficiency
基因位置（人類）
染色體	12號染色體
終止	57,768,986 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	126,888,875 bp
基因本體
分子功能	• iron ion binding; • 金屬離子結合; • monooxygenase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • calcidiol 1-monooxygenase activity;
細胞組分	• 細胞質; • 膜; • mitochondrial membranes; • mitochondrial outer membrane; • 粒線體;
生物學過程	• bone mineralization; • response to vitamin D; • calcium ion homeostasis; • response to interferon-gamma; • vitamin D metabolic process; • regulation of bone mineralization; • positive regulation of keratinocyte differentiation; • G1 to G0 transition; • response to estrogen; • response to lipopolysaccharide; • negative regulation of calcidiol 1-monooxygenase activity; • 蛻膜化; • vitamin metabolic process; • negative regulation of cell growth; • calcitriol biosynthetic process from calciol; • positive regulation of vitamin D 24-hydroxylase activity; • vitamin D catabolic process; • positive regulation of vitamin D receptor signaling pathway; • calcium ion transport; • negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
直系同源
	1594
	13115
	ENSG00000111012
	ENSMUSG00000006724
	O15528
	O35084
	NM_000785
	NM_010009
	NP_000776
	NP_034139
	維基資料
檢視/編輯人類	檢視/編輯小鼠

細胞色素 P450 27B1（英語：Cytochrome P450 27B1，縮寫CYP27B1）也被稱為25-羥基維生素 D3 1-α-羥化酶（25-Hydroxyvitamin D3 1-alpha-hydroxylase，EC 1.14.15.18），是細胞色素P450超家族的一員，由CYP27B1基因編碼，定位於粒線體內膜^[6]^[7]^[8]，在許多組織細胞中表現，如腎的近曲小管（英語：Proximal tubule）、皮膚角質形成細胞、免疫細胞^[9]、成骨細胞等^[10]，催化骨化二醇羥基化生成骨化三醇（維生素D的活性形式）^[11]：

骨化二醇 + 2 還原型 Adx + 2 H⁺ + O₂ ⇌ 骨化三醇 + 2 氧化型 Adx + H₂O

參考文獻

^ 與25-羥基維生素D3 1-α-羥化酶相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000111012 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000006724 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: cytochrome P450. （原始內容存檔於2009-05-11）.
^ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. Sep 1997, 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.
^ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications. Oct 1997, 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.
^ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (PDF). Nature Immunology. Mar 2007, 8 (3): 285–93 [2020-04-30]. PMID 17259988. doi:10.1038/ni1433. （原始內容 (PDF)存檔於2020-03-19）.
^ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology. Oct 2010, 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334  .
^ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. The Journal of Biological Chemistry. Dec 1972, 247 (23): 7528–32. PMID 4404596. doi:10.1016/S0021-9258(19)44557-2.

外部連結

GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis（頁面存檔備份，存於網際網路檔案館）
醫學主題詞表（MeSH）：Cytochrome+P-450+CYP27A1
Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

[1] 與25-羥基維生素D3 1-α-羥化酶相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000111012 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000006724 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-6] Entrez Gene: cytochrome P450. （原始內容存檔於2009-05-11）.

[pmid9295274-7] Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. Sep 1997, 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.

[pmid9344864-8] Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications. Oct 1997, 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.

[pmid17259988-9] Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (PDF). Nature Immunology. Mar 2007, 8 (3): 285–93 [2020-04-30]. PMID 17259988. doi:10.1038/ni1433. （原始內容 (PDF)存檔於2020-03-19）.

[pmid20739402-10] Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology. Oct 2010, 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334  .

[pmid4404596-11] Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. The Journal of Biological Chemistry. Dec 1972, 247 (23): 7528–32. PMID 4404596. doi:10.1016/S0021-9258(19)44557-2.

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