千金藤啶碱
化合物
千金藤啶碱(英语:Stepholidine)或左旋千金藤啶碱((−)-Stepholidine)是一种在河谷地不容(一种植物)中发现的原小檗碱生物碱。
左旋千金藤啶碱 | |
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IUPAC名 3,9-Dimethoxyberbine-2,10-diol | |
系统名 (13aS)-3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol | |
别名 | 左旋千金藤啶碱、(−)-千金藤啶碱、l-千金藤啶碱 |
识别 | |
CAS号 | 16562-13-3 ![]() |
PubChem | 6917970 |
ChemSpider | 5293188 |
SMILES |
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InChI |
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InChIKey | JKPISQIIWUONPB-HNNXBMFYBD |
MeSH | Stepholidine |
性质 | |
化学式 | C19H21NO4 |
摩尔质量 | 327.374 g/mol g·mol⁻¹ |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
参见
编辑参考资料
编辑- ^ Natesan S, Reckless GE, Barlow KB, et al. The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist. Psychopharmacology. August 2008, 199 (2): 275–89. PMID 18521575. S2CID 21653956. doi:10.1007/s00213-008-1172-1.
- ^ Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X. Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications. Curr. Med. Chem. 2007, 14 (28): 2996–3002 [2023-12-14]. PMID 18220736. doi:10.2174/092986707782794050. (原始内容存档于2012-07-20).
- ^ Jin GZ, Zhu ZT, Fu Y. (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions. Trends Pharmacol. Sci. January 2002, 23 (1): 4–7. PMID 11804640. doi:10.1016/S0165-6147(00)01929-5.
- ^ Fu W, Shen J, Luo X, et al. Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. Biophys. J. September 2007, 93 (5): 1431–41. PMC 1948031 . PMID 17468175. doi:10.1529/biophysj.106.088500.
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