埃巴单抗
化合物
埃巴单抗（INN：Edobacomab），开发代号为E5，是一种小鼠单克隆抗体，被研究作为革兰氏阴性细菌感染引起的败血症的可能治疗方法。
| 单克隆抗体 | |
|---|---|
| 种类 | 完整抗体 |
| 目標 | 内毒素 |
| 臨床資料 | |
| 给药途径 | 静脉注射 |
| ATC碼 |
|
| 识别信息 | |
| CAS号 | 141410-98-2  |
| ChemSpider | |
| UNII | |
延伸阅读
编辑- Greenman RL, Schein RM, Martin MA, Wenzel RP, MacIntyre NR, Emmanuel G, et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. JAMA. August 1991, 266 (8): 1097–102. PMID 1865542. doi:10.1001/jama.266.8.1097.
- Bone RC, Balk RA, Fein AM, Perl TM, Wenzel RP, Reines HD, et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Critical Care Medicine. June 1995, 23 (6): 994–1006. PMID 7774238. doi:10.1097/00003246-199506000-00003.
- Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, et al. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA. April 2000, 283 (13): 1723–30. PMID 10755499. doi:10.1001/jama.283.13.1723
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