普魯士藍 (醫用)


普魯士藍(Prussian blue),又名六氰基铁酸钾(potassium ferric hexacyanoferrate),用于治疗铊中毒放射性铯中毒[1] [4]。铊中毒時,除了洗胃活性炭强制利尿血液透析外,也可用它來治療[2] [5]。可以口服或鼻胃管给药[4] [5]普鲁士蓝也用于葡萄糖-6-磷酸脫氫酶缺乏症的尿液检测[6]

普魯士藍
普魯士藍
臨床資料
商品名英语Drug nomenclatureRadiogardase, others
AHFS/Drugs.comMonograph
给药途径口服
化学信息
摩尔质量859.24

副作用可能包括便秘低鉀血症和大便发黑[1] [2]。长期使用后,汗液可能会变成蓝色[2]。作用機轉是与铊和铯结合後,減少人體由消化道吸收它們[2]

普魯士藍在 1706 年左右发現[7]。已列入世界卫生组织基本药物标准清单[8]。截至2016年 (2016-Missing required parameter 1=month!) ,仅在德国、美国和日本取得医疗使用許可[9] [10] [11]。在世界上许多地区,包括已開發國家,医療用普鲁士蓝的取得常有困难[12]

参考文獻

编辑
  1. ^ 1.0 1.1 1.2 1.3 World Health Organization. WHO Model Formulary 2008. World Health Organization. 2009: 65. ISBN 9789241547659. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.
  2. ^ 2.0 2.1 2.2 2.3 2.4 Prussian Blue. The American Society of Health-System Pharmacists. [8 January 2017]. (原始内容存档于18 January 2017). "Prussian Blue". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
  3. ^ WHOCC - ATC/DDD Index. www.whocc.no. [13 September 2020]. (原始内容存档于21 October 2020). 
  4. ^ 4.0 4.1 Hamilton, Richart. Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. 2015: 472. ISBN 9781284057560. 
  5. ^ 5.0 5.1 Dart, Richard C. Medical Toxicology. Lippincott Williams & Wilkins. 2004: 248,279. ISBN 9780781728454. (原始内容存档于2017-01-16) (英语). 
  6. ^ Glucose-6-phosphate dehyrogenase deficiency — Medlibes: Online Medical Library. medlibes.com. [2017-05-03]. (原始内容存档于2016-09-15). 
  7. ^ Hall, Alan H.; Isom, Gary E.; Rockwood, Gary A. Toxicology of Cyanides and Cyanogens: Experimental, Applied and Clinical Aspects. John Wiley & Sons. 2015: 43. ISBN 9781118628942. (原始内容存档于2017-01-16) (英语). 
  8. ^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  9. ^ Goyer, Robert A. Metal Toxicology: Approaches and Methods. Elsevier. 2016: 93 [2017-01-15]. ISBN 9781483288567. (原始内容存档于2017-09-18) (英语). 
  10. ^ Dobbs, Michael R. Clinical Neurotoxicology: Syndromes, Substances, Environments. Elsevier Health Sciences. 2009: 280 [2017-01-15]. ISBN 0323052606. (原始内容存档于2017-01-16) (英语). 
  11. ^ Radioaktivität: Berliner Blau als Arzneimittel. Dtsch Arztebl. 1 July 2011 [10 December 2018]. (原始内容存档于14 December 2018) (德语). 
  12. ^ Archiver, Truthout. Fukushima's Cesium Spew - Deadly Catch-22s in Japan Disaster Relief. Truthout. 27 June 2011 [15 January 2017]. (原始内容存档于16 January 2017).