转化生长因子-β超家族

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1ktzA:312-412 1tgjA:312-412 1tgk :312-412 1tfg :314-414 2tgi :314-414 1kldA:290-390 1klcB:290-390 1klaA:290-390 1nyuB:318-426 1nysD:318-426 2b0uB:318-426 1s4yD:318-426 1m4uL:327-431 1bmp :328-431 1lxiA:327-431 1lx5A:327-431 1es7A:293-396 1rewB:293-396 1reuA:294-396 3bmpA:293-396 2bhkA:397-501 1waqA:397-501 1zkzA:324-429 1ehuA:290-393 1ehrA:290-393 1agqB:115-211

Transforming growth factor beta like domain
Transforming growth factor beta like domain
	人类的转化生长因子-β2的结构.
鑑定
標誌	TGF_beta
Pfam	PF00019（旧版）
InterPro（英语：InterPro）	IPR001839
PROSITE（英语：PROSITE）	PDOC00223
SCOP（英语：Structural Classification of Proteins）	1tfg / SUPFAM
Pfam
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1ktzA:312-412 1tgjA:312-412 1tgk :312-412 1tfg :314-414 2tgi :314-414 1kldA:290-390 1klcB:290-390 1klaA:290-390 1nyuB:318-426 1nysD:318-426 2b0uB:318-426 1s4yD:318-426 1m4uL:327-431 1bmp :328-431 1lxiA:327-431 1lx5A:327-431 1es7A:293-396 1rewB:293-396 1reuA:294-396 3bmpA:293-396 2bhkA:397-501 1waqA:397-501 1zkzA:324-429 1ehuA:290-393 1ehrA:290-393 1agqB:115-211

转化生长因子-β超家族（transforming growth factor beta superfamily，TGF-β superfamily）是生长因子中的一大家族。分为多个亚家族^[2]^[3]^[4]^[5]：

转化生长因子-β亚家族，包括：转化生长因子-β1、转化生长因子-β2、转化生长因子-β3
DVR（decapentaplegic Vg-related）亚家族，包括：
- 骨塑型蛋白（BMPs），如：骨塑型蛋白2、骨塑型蛋白8、骨塑型蛋白10、骨塑型蛋白15
- 生長分化因子（英语：Growth differentiation factor）（GDFs），如：生长分化因子1－3、生长分化因子5－11、生长分化因子15
激活素与抑制素，如：激活素A、激活素B、抑制素A、抑制素B
其他，如：Nodal^[6]

参看

转化生长因子-β
生長分化因子（英语：Growth differentiation factor）(Growth differentiation factor（英语：Growth differentiation factor）)

参考资料

^ Schlunegger MP, Grütter MG. An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. Nature. July 1992, 358 (6385): 430–4. PMID 1641027. doi:10.1038/358430a0.
^ Knight, P. G., & Glister, C. (2006). TGF-β superfamily members and ovarian follicle development, Reproduction, 132(2), 191-206. Retrieved Nov 18, 2022, from https://rep.bioscientifica.com/view/journals/rep/132/2/1320191.xml （页面存档备份，存于互联网档案馆）
^ Herpin A, Lelong C, Favrel P. Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans. Dev. Comp. Immunol. May 2004, 28 (5): 461–85. PMID 15062644. doi:10.1016/j.dci.2003.09.007.
^ Burt DW. Evolutionary grouping of the transforming growth factor-beta superfamily. Biochem. Biophys. Res. Commun. April 1992, 184 (2): 590–5. PMID 1575734. doi:10.1016/0006-291X(92)90630-4.
^ Burt DW, Law AS. Evolution of the transforming growth factor-beta superfamily (PDF). Prog. Growth Factor Res. 1994, 5 (1): 99–118 [2022-11-18]. PMID 8199356. S2CID 41326578. doi:10.1016/0955-2235(94)90020-5. hdl:20.500.11820/50fc2d69-c411-4835-9cd9-36bf4144bae4  . （原始内容存档 (PDF)于2022-11-18）.
^ Kumar A, Novoselov V, Celeste AJ, Wolfman NM, ten Dijke P, Kuehn MR. Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads. J Biol Chem. 2001 Jan 5;276(1):656-61. doi: 10.1074/jbc.M004649200. PMID 11024047.

[pmid1641027-1] Schlunegger MP, Grütter MG. An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. Nature. July 1992, 358 (6385): 430–4. PMID 1641027. doi:10.1038/358430a0.

[2] Knight, P. G., & Glister, C. (2006). TGF-β superfamily members and ovarian follicle development, Reproduction, 132(2), 191-206. Retrieved Nov 18, 2022, from https://rep.bioscientifica.com/view/journals/rep/132/2/1320191.xml （页面存档备份，存于互联网档案馆）

[3] Herpin A, Lelong C, Favrel P. Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans. Dev. Comp. Immunol. May 2004, 28 (5): 461–85. PMID 15062644. doi:10.1016/j.dci.2003.09.007.

[4] Burt DW. Evolutionary grouping of the transforming growth factor-beta superfamily. Biochem. Biophys. Res. Commun. April 1992, 184 (2): 590–5. PMID 1575734. doi:10.1016/0006-291X(92)90630-4.

[5] Burt DW, Law AS. Evolution of the transforming growth factor-beta superfamily (PDF). Prog. Growth Factor Res. 1994, 5 (1): 99–118 [2022-11-18]. PMID 8199356. S2CID 41326578. doi:10.1016/0955-2235(94)90020-5. hdl:20.500.11820/50fc2d69-c411-4835-9cd9-36bf4144bae4  . （原始内容存档 (PDF)于2022-11-18）.

[6] Kumar A, Novoselov V, Celeste AJ, Wolfman NM, ten Dijke P, Kuehn MR. Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads. J Biol Chem. 2001 Jan 5;276(1):656-61. doi: 10.1074/jbc.M004649200. PMID 11024047.

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