黄体生成素/绒毛膜促性腺激素受体
位於2號人類染色體的基因
黄体生成素/绒毛膜促性腺激素受体(英語:luteinizing hormone/choriogonadotropin receptor,缩写LHCGR也作 lutropin/choriogonadotropin receptor,LCGR或luteinizing hormone receptor,LHR )是一种主要出现在卵巢和睾丸的跨膜受体,但在一些性腺外的器官如子宫和乳房也有表达。该受体是G蛋白偶联受体(GPCR)的一种,既能与黄体生成素(LH)也能与绒毛膜促性腺激素(如人类的hCG)相互作用,其激活是在繁殖期间的荷尔蒙运作所需的。
LHCGR基因
编辑LHCGR位于人类基因组上的2號染色體p21区,接近类似的促卵泡激素受体(FSHR)基因,长约70Kbp(FSHR为54Kpb)[7],除了与FSHR相似外,还类似于促甲状腺激素受体(TSHR)。
历史
编辑馬丁·羅德貝爾与艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖。
相互作用
编辑参考文献
编辑- ^ 與黄体生成素/绒毛膜促性腺激素受体相關的疾病;在維基數據上查看/編輯參考.
- ^ 對luteinizing hormone/choriogonadotropin receptor起作用的藥物;在維基數據上查看/編輯參考.
- ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000138039 - Ensembl, May 2017
- ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000024107 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.
- ^ Hirakawa, Takashi; Galet Colette; Kishi Mikiko; Ascoli Mario. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200.
延伸阅读
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外部链接
编辑- Glycoprotein Hormone Receptors: LH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. (原始内容存档于2021-01-18).
- GRIS: Glycoprotein-hormone Receptor Information System
- 醫學主題詞表(MeSH):LH-hCG+Receptors