CBD-DMH

化合物

CBD-DMH(大麻二酚-二甲基庚基,英語:Cannabidiol-dimethylheptyl,也缩写为DMH-CBD),分子式C25H38O2,是一种人工合成的大麻素,可看做大麻二酚同系物,其侧链上的戊基被替换成二甲基庚基。[1][2][3][4]

CBD-DMH
识别信息
  • 5-(1,1-Dimethylheptyl)-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol
CAS号97452-63-6((−)-enantiomer)  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C25H38O2
摩尔质量370.57
3D模型(JSmol英语JSmol
  • CCCCCCC(C)(C)c1cc(c(c(c1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
  • InChI=1S/C25H38O2/c1-7-8-9-10-13-25(5,6)19-15-22(26)24(23(27)16-19)21-14-18(4)11-12-20(21)17(2)3/h14-16,20-21,26-27H,2,7-13H2,1,3-6H3/t20-,21+/m0/s1
  • Key:MPJURNPNPDQYSY-LEWJYISDSA-N

参考文献

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  1. ^ Leite JR, Carlini EA, Lander N, Mechoulam R. Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs. Pharmacology. 1982, 24 (3): 141–6. PMID 7071126. doi:10.1159/000137588. 
  2. ^ Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. British Journal of Pharmacology. October 2001, 134 (4): 845–52. PMC 1573017 . PMID 11606325. doi:10.1038/sj.bjp.0704327. 
  3. ^ Ben-Shabat S, Hanus LO, Katzavian G, Gallily R. New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity. Journal of Medicinal Chemistry. February 2006, 49 (3): 1113–7. PMID 16451075. doi:10.1021/jm050709m. 
  4. ^ Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z. Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells. Journal of Basic and Clinical Physiology and Pharmacology. May 2016, 27 (3): 289–96. PMID 26540221. doi:10.1515/jbcpp-2015-0071 . 

外部链接

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