CDX1

Caudal type homeobox 1尾型同源框1
Caudal type homeobox 1尾型同源框1
标识
代号	CDX1; MGC116915
扩展标识	遗传学：600746 鼠基因：88360 同源基因：1366 GeneCards: CDX1 Gene
基因本体论描述
分子功能	· RNA polymerase II distal enhancer sequence-specific DNA binding; · RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; · protein binding;
细胞成分	· nucleus;
生物过程	· organ morphogenesis; · anterior/posterior pattern specification; · positive regulation of transcription from RNA polymerase II promoter; · bone morphogenesis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	1044
Ensembl	ENSG00000113722
UniProt	P47902
mRNA序列	NM_001804
蛋白序列	NP_001795
基因位置	Chr 5:; 149.55 – 149.56 Mb
PubMed查询	[1]
	查; 论; 编;

同源框蛋白CDX-1（Homeobox protein CDX-1）是一种由基因CDX1编码的蛋白质。^[1]^[2]

该基因是尾型同源框转录因子基因家族的一员。其编码的DNA结合蛋白用以调控肠道特异性基因的表达和肠上皮细胞的分化。已知它能诱导肠道碱性磷酸酶的表达，并抑制β-连环素和T细胞因子的转录活性^[2]。

参考文献

^ Bonner CA, Loftus SK, Wasmuth JJ. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics. Feb 1996, 28 (2): 206–11. PMID 8530027. doi:10.1006/geno.1995.1132.
^ ^2.0 ^2.1 Entrez Gene: CDX1 caudal type homeobox transcription factor 1.

延伸阅读

Dixon, Jill; Edwards, Sara J.; Gladwin, Amanda J.; Dixon, Michael J.; Loftus, Stacie K.; Bonner, Cynthia A.; Koprivnikar, Kathryn; Wasmuth, John J. Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group. Nat. Genet. 1996, 12 (2): 130–6. PMID 8563749. doi:10.1038/ng0296-130.
Mallo GV, Rechreche H, Frigerio JM; et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer. 1997, 74 (1): 35–44. PMID 9036867. doi:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1.
Mizoshita T, Inada K, Tsukamoto T; et al. Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer. 2002, 4 (4): 185–91. PMID 11846061. doi:10.1007/PL00011741.
Suh ER, Ha CS, Rankin EB; et al. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J. Biol. Chem. 2002, 277 (39): 35795–800. PMID 12124393. doi:10.1074/jbc.M205567200.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Domon-Dell C, Schneider A, Moucadel V; et al. Cdx1 homeobox gene during human colon cancer progression. Oncogene. 2003, 22 (39): 7913–21. PMID 12970739. doi:10.1038/sj.onc.1206756.
Wong NA, Britton MP, Choi GS; et al. Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (2): 574–9. PMC 327189  . PMID 14704280. doi:10.1073/pnas.0307190101.
Rankin EB, Xu W, Silberg DG, Suh E. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286 (5): G872–80. PMID 14715525. doi:10.1152/ajpgi.00326.2003.
Béland M, Pilon N, Houle M; et al. Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex. Mol. Cell. Biol. 2004, 24 (11): 5028–38. PMC 416402  . PMID 15143193. doi:10.1128/MCB.24.11.5028-5038.2004.
Guo RJ, Huang E, Ezaki T; et al. Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J. Biol. Chem. 2004, 279 (35): 36865–75. PMID 15215241. doi:10.1074/jbc.M405213200.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Alkhoury F, Malo MS, Mozumder M; et al. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289 (2): G285–90. PMID 15774940. doi:10.1152/ajpgi.00037.2005.
Wong NA, Wilding J, Bartlett S; et al. CDX1 is an important molecular mediator of Barrett's metaplasia. Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (21): 7565–70. PMC 1140438  . PMID 15894614. doi:10.1073/pnas.0502031102.

外部链接

醫學主題詞表（MeSH）：CDX1+protein,+human

Template:Gene-5-stub

CDX1引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[pmid8530027-1] Bonner CA, Loftus SK, Wasmuth JJ. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics. Feb 1996, 28 (2): 206–11. PMID 8530027. doi:10.1006/geno.1995.1132.

[entrez-2] 2.0 ^2.1 Entrez Gene: CDX1 caudal type homeobox transcription factor 1.

[1]

[2]