IL7RA

IL7R
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3DI2、3DI3、3UP1
識別號
别名	IL7R；, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
外部ID	OMIM：146661 MGI：96562 HomoloGene：1646 GeneCards：IL7R
相關疾病
	多发性硬化症、溃疡性结肠炎、1型糖尿病
基因位置（人类）
染色体	5號染色體
终止	35,879,603 bp
基因位置（小鼠）
染色体	小鼠15号染色体
终止	9,530,262 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• antigen binding; • interleukin-7 receptor activity; • 血浆蛋白结合; • cytokine receptor activity;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • 細胞外區域; • external side of plasma membrane; • clathrin-coated vesicle membrane;
生物學過程	• regulation of cell size; • regulation of DNA recombination; • positive regulation of T cell differentiation in thymus; • homeostasis of number of cells; • negative regulation of T cell mediated cytotoxicity; • cell surface receptor signaling pathway; • B cell proliferation; • T cell differentiation; • positive regulation of gene expression; • 免疫反应; • cell morphogenesis; • 淋巴结的发生; • immunoglobulin production; • 訊息傳遞; • interleukin-7-mediated signaling pathway; • positive regulation of cell population proliferation; • positive regulation of receptor signaling pathway via STAT; • membrane organization; • negative regulation of T cell apoptotic process;
	Sources:Amigo / QuickGO
直系同源
	3575
	16197
	ENSG00000168685
	ENSMUSG00000003882
	P16871
	P16872
	NM_002185
	NM_008372; NM_001355680
	NP_002176
	NP_032398; NP_001342609
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白介素-7受体α亚基（Interleukin-7 receptor subunit alpha，缩写IL7R-α或IL7RA）也称为分化簇127（CD127，cluster of differentiation 127）是一种细胞表面蛋白质，由人类基因 IL7R 编码^[6]，与γ链（CD132）共同组成白介素-7受体（IL7R，一种I型细胞因子受体），能结合白细胞介素-7（IL7）与胸腺基质淋巴细胞生成素（TSLP）^[7]。

参考资料

^ 與IL7R相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000168685 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000003882 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: IL7R interleukin 7 receptor.
^ Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. March 1990, 60 (6): 941–51. PMID 2317865. S2CID 45181020. doi:10.1016/0092-8674(90)90342-C.

外部链接

醫學主題詞表（MeSH）：IL7R+protein,+human
PDB中UniProt可用的所有結構信息之概述：P16871 (Human Interleukin-7 receptor subunit alpha) 在PDBe-KB（英语：PDBe-KB）。
PDB中UniProt可用的所有結構信息之概述：P16872 (Mouse Interleukin-7 receptor subunit alpha) 在PDBe-KB（英语：PDBe-KB）。

[1] 與IL7R相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000168685 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000003882 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-6] Entrez Gene: IL7R interleukin 7 receptor.

[pmid2317865-7] Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. March 1990, 60 (6): 941–51. PMID 2317865. S2CID 45181020. doi:10.1016/0092-8674(90)90342-C.

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