Ki-67 (蛋白質)

Ki-67MKI67)是一種由人MKI67基因編碼的蛋白質[5][6][7]。該蛋白與細胞的增殖密切相關,在有絲分裂期以及分裂間期的細胞(G1、S、G2、M期)中都能檢出Ki-67蛋白,有絲分裂停止的細胞(G0期)中則無Ki-67蛋白質存在。另外,研究發現使Ki-67失活可以抑制rRNA的合成,提示Ki-67蛋白與rRNA(核糖體RNA)的轉錄密切相關[7][8]

Ki-67
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名MKI67;, marker of proliferation Ki-67, KIA, MIB-, MIB-1, PPP1R105
外部IDOMIM176741 MGI106035 HomoloGene1814 GeneCardsMKI67
基因位置(人类
10號染色體
染色体10號染色體[1]
10號染色體
Ki-67的基因位置
Ki-67的基因位置
基因座10q26.2起始128,096,659 bp[1]
终止128,126,423 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_001145966
​NM_002417

NM_001081117

蛋白序列

NP_001139438
​NP_002408

NP_001074586

基因位置​(UCSC)Chr 10: 128.1 – 128.13 MbChr 7: 135.29 – 135.32 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

參考

编辑
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000148773 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000031004 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Entrez Gene: Antigen identified by monoclonal antibody Ki-67. 
  6. ^ Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van Kessel AH, Verheijen R, Ramaekers FC. Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10. Hum. Genet. October 1989, 83 (3): 297–9. PMID 2571566. doi:10.1007/BF00285178. 
  7. ^ 7.0 7.1 Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J. Cell. Physiol. March 2006, 206 (3): 624–35. PMID 16206250. doi:10.1002/jcp.20494. 
  8. ^ Rahmanzadeh R, Hüttmann G, Gerdes J, Scholzen T. Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis. Cell Prolif. June 2007, 40 (3): 422–30. PMID 17531085. doi:10.1111/j.1365-2184.2007.00433.x. 

外部連結

编辑