LAMA1

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白質在人体内由LAMA1基因编码。

LAMA1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2JD4
識別號
别名	LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部ID	OMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相關疾病
2型糖尿病、​ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome
為以下藥物的標靶
ocriplasmin
基因位置（人类） 染色体 18號染色體 基因座 18p11.31 起始 6,941,742 bp 终止 7,117,797 bp
基因位置（小鼠） 染色体 小鼠17号染色体 基因座 17 E1.1|17 38.8 cM 起始 68,004,254 bp 终止 68,129,642 bp
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • signaling receptor binding • extracellular matrix structural constituent • 血浆蛋白结合 • protein C-terminus binding • glycosphingolipid binding 細胞組分 • 细胞外间质 • 細胞外區域 • 基底膜 • laminin-1 complex • laminin-3 complex • 細胞外空間 • 膜 • cell-cell junction • laminin complex • collagen-containing extracellular matrix 生物學過程 • cell surface receptor signaling pathway • regulation of cell adhesion • 細胞粘附 • extracellular matrix organization • regulation of cell migration • regulation of embryonic development • morphogenesis of an epithelial sheet • protein phosphorylation • 组织发生 • neuron projection development • establishment of epithelial cell apical/basal polarity • retina development in camera-type eye • epithelial tube branching involved in lung morphogenesis • branching involved in salivary gland morphogenesis • retinal blood vessel morphogenesis • 轴突导向 • animal organ morphogenesis • camera-type eye development • blood vessel morphogenesis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	284217	16772
Ensembl	ENSG00000101680	ENSMUSG00000032796
UniProt	P25391	P19137
mRNA​序列	NM_005559	NM_008480
蛋白序列	NP_005550	NP_032506
基因位置​（UCSC）	Chr 18: 6.94 – 7.12 Mb	Chr 17: 68 – 68.13 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

相互作用

层粘蛋白亚基α1会与FBLN2发生蛋白质相互作用。

拓展阅读

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