N-甲基哌嗪
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! colspan="2" style="font-size:120%; text-align:center; background:#d6e0dc;" | N-Methylpiperazine
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|align="center" colspan="2" bgcolor="#ffffff" |
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| align="center" colspan="2" style="max-width:305px; word-wrap: break-word;"|IUPAC名
1-Methylpiperazine
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| 别名
|
- 4-Methylpiperazine
- p-Methylpiperazine
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! style="background:#D6E0DC; text-align:center;" colspan="2" | 识别
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| CAS号 |109-01-3 |- | PubChem | 53167 |- | ChemSpider | 48024 |- | SMILES
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- CN1CCNCC1
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| UN编号 | 2920 |- ! style="background:#D6E0DC; text-align:center;" colspan="2" | 性质 |- | 化学式 | C5H12N2 |- | 摩尔质量 | 100.16 g·mol−1 |-
| 熔点 | -6 °C(267 K) |- | 沸点 | 138 °C(411 K) |-
! style="background:#D6E0DC; text-align:center;" colspan="2" | 危险性
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| align="center" colspan="2" |GHS危险性符号
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| GHS提示词
| Danger
|-
| H-术语
| H226, H312, H314, H317, H318, H330, H331, H332
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| P-术语
| P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P272, P280, P284, P301+330+331
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| NFPA 704 |
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! style="background:#D6E0DC; text-align:center;" colspan="2" | 相关物质 |-
| 相关化学品
| Piperazine, 4-methylpyridine
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| style="background:#D6E0DC; text-align:center;" colspan="2" | 若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。
|}
N-甲基哌嗪是一种杂环有机化合物,化学式为C5H12N2,它是有机合成中的常用砌块。[1]例如,它可用于苯甲嗪[2]、美克洛嗪和西地那非等药物的合成。它的锂盐可用于芳基醛的保护。[3]
合成
编辑参考文献
编辑- ^ 1-methylpiperazine. European Chemicals Agency. [2021-10-07]. (原始内容存档于2021-05-09).
- ^ Vardanyan, Ṛuben & Hruby, Victor J. Synthesis of Essential Drugs. : 226.
- ^ Comins, Daniel L.; Joseph, Sajan P. Lithium N-Methylpiperazide. Encyclopedia of Reagents for Organic Synthesis. 2001. ISBN 0471936235. doi:10.1002/047084289X.rl128.
- ^ US 4845218,「Preparation of N-Methylpiperazine」,发行于1989-07-04 (页面存档备份,存于互联网档案馆) 存档副本. [2021-10-07]. 原始内容存档于2019-05-14.
- ^ Catalytic synthesis of N-methylpiperazine from diethanolamine and methylamine by cyclodehydration reaction (PDF). Indian Journal of Chemical Technology. 1994, 1 (November): 359–360 [2021-10-07]. (原始内容存档 (PDF)于2021-10-07).