PAS结构域(英語:PAS domain)也称为PAS折叠(英語:PAS fold)是一种在细菌古菌真核生物中都存在的蛋白质结构域[2]。其功能为检测小分子物质,如检测氧气EPAS1[3][4][5]

PAS折叠
细菌的氧气感受蛋白fixL的PAS结构域的晶体结构[1]。蛋白以飘带图展示,其中N-末端为蓝色,C-末端为红色,中间为血红素
鑑定
標誌PAS
PfamPF00989旧版
InterPro英语InterProIPR013767
SMART英语Simple Modular Architecture Research ToolPAS
PROSITE英语PROSITEPDOC50112
SCOP英语Structural Classification of Proteins2phy / SUPFAM
CDD英语Conserved Domain Databasecd00130

参考文献

编辑
  1. ^ PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. July 2003, 42 (25): 7701–8 [2023-01-04]. PMID 12820879. doi:10.1021/bi0343370. (原始内容存档于2023-01-20). 
  2. ^ Henry, Jonathan T.; Crosson, Sean. Ligand-binding PAS domains in a genomic, cellular, and structural context. Annual Review of Microbiology. 1 January 2011, 65: 261–286. PMC 3298442 . PMID 21663441. doi:10.1146/annurev-micro-121809-151631. 
  3. ^ Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallographica Section D. 1 October 2015, 71 (10): 2127–2136. PMID 26457436. doi:10.1107/S139900471501384X. 
  4. ^ Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith. Structure and signaling mechanism of Per-ARNT-Sim domains. Structure. 14 October 2009, 17 (10): 1282–1294. PMC 3092527 . PMID 19836329. doi:10.1016/j.str.2009.08.011. 
  5. ^ Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLOS Biology. 28 April 2009, 7 (4): e1000094. PMC 2671562 . PMID 19402751. doi:10.1371/journal.pbio.1000094.