TAS2R40
位於7號人類染色體的基因
味觉感受器，类型2，成员40，TAS2R40是一个人类基因组中TAS2R40基因编码的蛋白质，是苦味味觉感受器的一员。[1][2]
| 味觉感受器，类型2，成员40 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R40; GPR60; T2R40; T2R58 | ||||||||||||
| 扩展标识 | 遗传学：613964 鼠基因：2681312 同源基因：47977 IUPHAR: GeneCards: TAS2R40 Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 259286 | 387515 | |||||||||||
| Ensembl | ENSG00000221937 | ENSMUSG00000051917 | |||||||||||
| UniProt | P59535 | Q7TQB8 | |||||||||||
| mRNA序列 | NM_176882 | NM_001001453 | |||||||||||
| 蛋白序列 | NP_795363 | NP_001001453 | |||||||||||
| 基因位置 |
Chr 7: 142.92 – 142.92 Mb |
Chr 6: 42.22 – 42.22 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
另见
编辑参考文献
编辑- ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
- ^ Entrez Gene: TAS2R40 taste receptor, type 2, member 40.
延伸阅读
编辑- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Scherer SW, Cheung J, MacDonald JR; et al. Human chromosome 7: DNA sequence and biology.. Science. 2003, 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
- Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
