地诺帕明

地诺帕明
临床资料
AHFS/Drugs.com	国际药品名称
给药途径	口服（片剂）
ATC码	未分配;
法律规范状态
法律规范	Rx-only (JP);
识别信息
	IUPAC命名法 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol; ;
CAS号	71771-90-9
PubChem CID	71754;
IUPHAR/BPS	534;
ChemSpider	64795;
UNII	V5F60UPD8P;
KEGG	D02614;
ChEMBL	ChEMBL493682;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID8045800 ;
ECHA InfoCard	100.163.233
化学信息
化学式	C18H23NO4
摩尔质量	317.39 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C;

地诺帕明（INN：denopamine）是一种强心药，它可充当β₁肾上腺素受体激动剂。^[1]它用于治疗心绞痛，^[2]也可能在治疗充血性心力衰竭^[3] 和清除肺水肿方面具有潜在用途。^[4]它在日本以商品名Kalgut（カルグート）上市，有5毫克和10毫克片剂以及5%细颗粒剂可供选择。^[5]

参考资料

^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119.
^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012.
^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223  .
^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161  .
^ Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. （原始内容存档 (PDF)于2024-03-31）（Japanese）.

[1] Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119.

[2] Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012.

[3] Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223  .

[4] Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161  .

[5] Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. （原始内容存档 (PDF)于2024-03-31）（Japanese）.

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