地諾帕明

地諾帕明
臨床資料
AHFS/Drugs.com	國際藥品名稱
給藥途徑	口服（片劑）
ATC碼	未分配;
法律規範狀態
法律規範	Rx-only (JP);
識別資訊
	IUPAC命名法 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol; ;
CAS號	71771-90-9
PubChem CID	71754;
IUPHAR/BPS	534;
ChemSpider	64795;
UNII	V5F60UPD8P;
KEGG	D02614;
ChEMBL	ChEMBL493682;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID8045800 ;
ECHA InfoCard	100.163.233
化學資訊
化學式	C18H23NO4
摩爾質量	317.39 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C;

地諾帕明（INN：denopamine）是一種強心藥，它可充當β₁腎上腺素受體激動劑。^[1]它用於治療心絞痛，^[2]也可能在治療充血性心力衰竭^[3] 和清除肺水腫方面具有潛在用途。^[4]它在日本以商品名Kalgut（カルグート）上市，有5毫克和10毫克片劑以及5%細顆粒劑可供選擇。^[5]

參考資料

^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119.
^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012.
^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223  .
^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161  .
^ Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. （原始內容存檔 (PDF)於2024-03-31）（Japanese）.

[1] Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119.

[2] Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012.

[3] Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223  .

[4] Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161  .

[5] Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. （原始內容存檔 (PDF)於2024-03-31）（Japanese）.

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