氟替卡松
化合物
氟替卡松(英语:fluticasone)为一种综合的糖皮质激素。[1]
临床资料 | |
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AHFS/Drugs.com | Monograph |
怀孕分级 |
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给药途径 | 鼻腔内吸入,局部涂搽 |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物利用度 | 0.51% (鼻腔内) |
血浆蛋白结合率 | 91% |
药物代谢 | 鼻腔内 肝脏(CYP3A4-中介) |
生物半衰期 | 10小时 |
排泄途径 | 肾脏 |
识别信息 | |
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CAS号 | 80474-14-2((丙酸酯)) 90566-53-3 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C22H27F3O4S |
摩尔质量 | 444.508 g/mol |
3D模型(JSmol) | |
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参见
编辑注释
编辑- ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J., Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins: 600, 2012 [2013-10-28], ISBN 1451153597, (原始内容存档于2014-01-01).
- ^ Spratto, George R.; Woods, Adrienne L., Delmar Nurse's Drug Handbook 2012, Cengage Learning: 748, 2012 [2013-10-28], ISBN 1111310653, (原始内容存档于2014-01-01).
参考文献
编辑- Jarvis B., Faulds D. (1999): Inhaled fluticasone propionate: A review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs, 57(5), 769–803. PMID 10353302
- Johnson M. (1995): The anti-inflammatory profile of fluticasone propionate. Allergy, 50(23), 11–14. PMID 7604948
- Keating G.M., McCormack P.L. (2007): Salmeterol/fluticasone propionate: a review of its use in the treatment of chronic obstructive pulmonary disease. Drugs, 67(16), 2383–2405. PMID 17983257
- Reynolds N.A., Lyseng-Williamson K.A., Wiseman L.R. (2005): Inhaled salmeterol/fluticasone propionate: a review of its use in asthma. Drugs, 65(12), 1715–1734. PMID 16060707
- Spencer C.M., Jarvis B. (1999): Salmeterol/fluticasone propionate combination. Drugs, 57(6), 933–940. PMID 10400406
- Staresinic A.G., Sorkness C.A. (2000): Fluticasone propionate: A potent inhaled corticosteroid for the treatment of asthma. Expert Opin Pharmacother, 1(6), 1227-1244. PMID 11249490
- Avamys, Zusammenfasuung der Merkmale des Arzneimittels (PDF; 440 kB), Stand Dezember 2012, Europäische Arzneimittelagentur.