血清素转运体

血清素转运体, 5-羟色胺转运体 (SERT 或 5-HTT)，钠离子依赖型血清素转运体 及 溶质载体家族6成员4 是一种在人体中被SLC6A4基因所编码的蛋白质。SERT 是一种负责传送突触间隙的血清素到突触前神经元的单胺转运蛋白。

Solute carrier family 6 (neurotransmitter transporter), member 4
标识
代号	SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT
扩展标识	遗传学：182138 鼠基因：96285 同源基因：817 ChEMBL: 228 GeneCards: SLC6A4 Gene
基因本体论描述 分子功能 · serotonin:sodium symporter activity · protein binding · monoamine transmembrane transporter activity · serotonin transmembrane transporter activity · myosin binding · syntaxin-1 binding · Rab GTPase binding · cocaine binding · protein homodimerization activity · nitric-oxide synthase binding · actin filament binding 细胞成分 · cytosol · plasma membrane · integral component of plasma membrane · endosome membrane · endomembrane system · neuron projection · membrane raft 生物过程 · response to hypoxia · serotonin transport · synaptic transmission · response to nutrient · memory · circadian rhythm · response to toxic substance · positive regulation of gene expression · monoamine transport · thalamus development · negative regulation of cerebellar granule cell precursor proliferation · negative regulation of synaptic transmission, dopaminergic · response to estradiol · social behavior · vasoconstriction · response to drug · sperm ejaculation · negative regulation of neuron differentiation · positive regulation of cell cycle · negative regulation of organ growth · brain morphogenesis · protein oligomerization · protein homooligomerization · serotonin uptake · transmembrane transport · cellular response to retinoic acid · cellular response to cGMP Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6532	15567
Ensembl	ENSG00000108576	ENSMUSG00000020838
UniProt	P31645	Q60857
mRNA序列	NM_001045	NM_010484
蛋白序列	NP_001036	NP_034614
基因位置	Chr 17: 30.19 – 30.24 Mb	Chr 11: 77 – 77.03 Mb
PubMed查询	[1]	[2]

功能

血清素转运体将血清素从突触间隙发送回突触终扣，阻止了血清素的作用，同时令突触前神经元能够重新运用突触间隙的血清素。

神经元之间的沟通是由神经传导物质，如细胞之间的血清素转运来进行。因血清素转运体使血清素得以重新运用；平冲了血清素于突触间隙的浓度，因此其作用于接收神经元的受体上。

血清素转运体也存在于血小板中，作用为一种使血管收缩的物质。

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  血清素