非诺特罗

化合物

非诺特罗(Fenoterol) 是一种用来扩张呼吸道β2肾上腺素受体激动药。非诺特罗 属于拟交感神经药 β2 刺激剂和气喘药。

非诺特罗
临床资料
AHFS/Drugs.comMicromedex详细消费者药物信息
给药途径Inhalation (MDI英语Metered-dose inhaler)
ATC码
法律规范状态
法律规范
药物动力学数据
生物半衰期6.5小时左右 [1][2][3][4]
识别信息
  • (RR,SS)-5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol
CAS号13392-18-2  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.205.960 编辑维基数据链接
化学信息
化学式C17H21NO4
摩尔质量303.35 g/mol
3D模型(JSmol英语JSmol
  • Oc1cc(cc(O)c1)C(O)CNC(C)Cc2ccc(O)cc2
  • InChI=1S/C17H21NO4/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13/h2-5,7-9,11,17-22H,6,10H2,1H3 checkY
  • Key:LSLYOANBFKQKPT-UHFFFAOYSA-N checkY

非诺特罗 由勃林格殷格翰制造和销售,商品名称为:Berotec N备劳喘)。制造商有时也会把非诺特罗与ipratropium混和后销售,商品名称为 Berodual N备喘全)。

医学用途

编辑

非诺特罗 是短效的 β2刺激剂。当非诺特罗使用超过建议的医疗用剂量(每日最多只能吸入八剂、每剂量需间隔至少五分钟,若气喘状况没好转,则再吸入第二剂[5])时,也会成为β1 受体英语Beta-1 adrenergic receptor刺激剂。

使用者可以于运动前吸入一剂,预防稍后因运动所诱发的气喘(气管痉挛)。[6]

副作用

编辑

已知曾有患者在急性气喘发作时吸入了高达80剂的非诺特罗,最终因而死亡。当患者发现非诺特罗已经无法缓解气喘时,应当停止吸入非诺特罗,并尽快就医。[7][8]

 
Berotec
 
Berotec 备劳喘

参见

编辑

文献来源

编辑
  1. ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. (原始内容存档于2019-08-25). 
  2. ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. (原始内容存档于2020-11-27). 
  3. ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. (原始内容存档于2021-04-20). 
  4. ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x. 
  5. ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. (原始内容存档于2020-11-23). Dosage / Direction for Use:
    Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
    Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
    Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day.
     
  6. ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. (原始内容存档于2018-06-25). 
  7. ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016. 
  8. ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.