1,3,3,5,5-五甲基环己胺

化合物

1,3,3,5,5-五甲基环己胺(英语:1,3,3,5,5-pentamethylcyclohexanamine,或称为Neramexane)是一种美金刚胺相关药物,分子式为C11H23N[1],作为一种NMDA受体拮抗剂[2],具有神经保护作用[3]

1,3,3,5,5-五甲基环己胺
临床资料
ATC码
  • 未分配
识别信息
  • 1,3,3,5,5-pentamethylcyclohexanamine
CAS号219810-59-0  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.107.752 编辑维基数据链接
化学信息
化学式C11H23N
摩尔质量169.31 g·mol−1
3D模型(JSmol英语JSmol
  • CC1(CC(CC(C1)(C)N)(C)C)C
  • InChI=1S/C11H23N/c1-9(2)6-10(3,4)8-11(5,12)7-9/h6-8,12H2,1-5H3 ☒N
  • Key:OGZQTTHDGQBLBT-UHFFFAOYSA-N ☒N

参考文献

编辑
  1. ^ Gilling K, Jatzke C, Wollenburg C, Vanejevs M, Kauss V, Jirgensons A, Parsons CG. A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists--in vitro characterization. Journal of Neural Transmission. 2007, 114 (12): 1529–37. PMID 17728997. S2CID 8654883. doi:10.1007/s00702-007-0792-7. 
  2. ^ Danysz W, Parsons CG, Jirgensons A, Kauss V, Tillner J. Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists. Current Pharmaceutical Design. 2002, 8 (10): 835–43. PMID 11945134. doi:10.2174/1381612024607117. 
  3. ^ Danysz W, Parsons CG. Neuroprotective potential of ionotropic glutamate receptor antagonists. Neurotoxicity Research. March 2002, 4 (2): 119–26. PMID 12829411. S2CID 9413469. doi:10.1080/10298420290015872. 

外部链接

编辑