血管紧张素Ⅰ转化酶

血管紧张素Ⅰ转化酶
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1O86、1O8A、1UZE、1UZF、2C6F、2C6N、2IUL、2IUX、2OC2、2XY9、2XYD、2YDM、3BKK、3BKL、3NXQ、4APH、4APJ、3L3N、4BXK、4BZR、4BZS、4C2N、4C2O、4C2P、4C2Q、4C2R、4CA5、4CA6、4UFA、4UFB、5AMB、5AM9、5AM8、5AMC、5AMA
识别号
别名	ACE；, angiotensin I converting enzyme, ACE1, CD143, DCP, DCP1, ICH, MVCD3, Angiotensin-converting enzyme
外部ID	OMIM：106180 MGI：87874 HomoloGene：37351 GeneCards：ACE
相关疾病
	糖尿病肾病、高血压
为以下药物的标靶
	卡托普利、cilazapril、依那普利、咪达普利、群多普利、佐芬普利、咪达普利、delapril、moexipril、benazepril hydrochloride、enalapril maleate、perindopril erbumine、quinapril hydrochloride
基因位置（人类）
染色体	17号染色体
终止	63,498,380 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	105,880,790 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• tripeptidyl-peptidase activity; • 锌离子结合; • exopeptidase activity; • endopeptidase activity; • 金属离子结合; • mitogen-activated protein kinase binding; • bradykinin receptor binding; • 肽酶活性; • 血浆蛋白结合; • carboxypeptidase activity; • chloride ion binding; • actin binding; • mitogen-activated protein kinase kinase binding; • 水解酶活性; • metallodipeptidase activity; • metallopeptidase activity; • peptidyl-dipeptidase activity; • dipeptidyl-peptidase activity;
细胞组分	• 细胞质; • integral component of membrane; • 核内体; • 膜; • 溶酶体; • 外排体; • external side of plasma membrane; • 细胞外区域; • 细胞膜; • 细胞外空间;
生物学过程	• regulation of renal output by angiotensin; • antigen processing and presentation of peptide antigen via MHC class I; • amyloid-beta metabolic process; • angiotensin maturation; • blood vessel remodeling; • regulation of vasoconstriction; • hematopoietic stem cell differentiation; • regulation of angiotensin metabolic process; • regulation of smooth muscle cell migration; • mononuclear cell proliferation; • regulation of systemic arterial blood pressure by renin-angiotensin; • arachidonic acid secretion; • peptide catabolic process; • blood vessel diameter maintenance; • 蛋白酶解; • 肾的发生; • neutrophil mediated immunity; • positive regulation of systemic arterial blood pressure; • 精子发生; • 血压调节; • posttranscriptional regulation of gene expression; • negative regulation of gene expression; • negative regulation of protein binding; • positive regulation of protein binding; • hormone catabolic process; • 心肌收缩能力; • positive regulation of protein tyrosine kinase activity; • cell proliferation in bone marrow; • positive regulation of peptidyl-tyrosine autophosphorylation; • regulation of hematopoietic stem cell proliferation; • negative regulation of gap junction assembly; • positive regulation of peptidyl-cysteine S-nitrosylation; • positive regulation of blood pressure;
	Sources:Amigo / QuickGO
直系同源
	1636
	11421
	ENSG00000159640
	ENSMUSG00000020681
	P12821
	P09470
NM_000789; NM_001178057; NM_152830; NM_152831; NM_001382700;
	NM_001382701; NM_001382702
	NM_009598; NM_207624; NM_001281819
NP_000780; NP_001171528; NP_690043; NP_001369629; NP_001369630;
	NP_001369631
	NP_001268748; NP_033728; NP_997507
	维基数据
查看/编辑人类	查看/编辑小鼠

血管紧张肽I转化酶
命名
系统命名
缩写
识别码
EC编号	3.4.15.1
CAS号	9015-82-1
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

血管紧张肽I转化酶（英语：Angiotensin-converting enzyme，又称为血管紧张素转化酶，简称为ACE，EC 3.4.15.1）是一种外肽酶。

功能

肾素 - 血管紧张素 - 醛固酮系统示意图

肾素 - 血管紧张素系统的解剖图，显示出血管紧张素Ⅰ转化酶在肺中的作用

主要功能有以下两个：

催化血管紧张素I转化为血管紧张素II；
使缓激肽失活。

血管紧张素转化酶因这两种功能而成为治疗高血压、心力衰竭、2型糖尿病和糖尿病肾病等疾病的理想靶点。血管紧张素转化酶抑制剂能减少血管紧张素II的生成，并增加缓激肽的活性。

此外，ACE也能催化血管紧张素-(1-9)转化为血管紧张素-(1-7)。

同义词

血管紧张素转化酶（ACE）也被称作：

肽基二肽酶A （peptidyl dipeptidase A）
羧基组织蛋白酶（carboxycathepsin）
激肽酶II （kininase II）
CD143
ACE1

参见

延伸阅读

Niu T, Chen X, Xu X. Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. Drugs. 2002, 62 (7): 977–93. PMID 11985486. doi:10.2165/00003495-200262070-00001.
Roĭtberg GE, Tikhonravov AV, Dorosh ZhV. [Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome]. Ter. Arkh. 2004, 75 (12): 72–7. PMID 14959477.
Vynohradova SV. [The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology]. Tsitol. Genet. 2005, 39 (1): 63–70. PMID 16018179.
König S, Luger TA, Scholzen TE. Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin. Exp. Dermatol. 2006, 15 (10): 751–61. PMID 16984256. doi:10.1111/j.1600-0625.2006.00472.x.
Sabbagh AS; Otrock ZK; Mahfoud ZR; et al. Angiotensin-converting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature. Mol. Biol. Rep. 2007, 34 (1): 47–52. PMID 17103020. doi:10.1007/s11033-006-9013-y.
Castellon R, Hamdi HK. Demystifying the ACE polymorphism: from genetics to biology. Curr. Pharm. Des. 2007, 13 (12): 1191–8. PMID 17504229. doi:10.2174/138161207780618902.
Lazartigues E, Feng Y, Lavoie JL. The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Curr. Pharm. Des. 2007, 13 (12): 1231–45. PMID 17504232. doi:10.2174/138161207780618911.

外部链接

医学主题词表（MeSH）：Angiotensin+Converting+Enzyme

^ 與血管紧张素Ⅰ转化酶相關的疾病；在維基數據上查看/編輯參考.
^ 對血管紧张素Ⅰ转化酶起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000159640 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020681 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[1] 與血管紧张素Ⅰ转化酶相關的疾病；在維基數據上查看/編輯參考.

[2] 對血管紧张素Ⅰ转化酶起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000159640 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020681 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[1]

[2]

[3]

[4]

[5]

[6]