脑源性神经营养因子
(重定向自BDNF)
脑源性神经营养因子(brain-derived neurotrophic factor,BDNF,abrineurin[1])是人脑中的一种蛋白质,由脑源性神经营养因子基因生成。脑源性神经营养因子是神经营养因子中的一种,这种因子存在于人的神经系统中。
BDNF是大脑中含量最丰富的蛋白质,在脑部可以促进神经元 (神经细胞) 的生长,也促进大脑神经细胞突触的成形。简单来说,就是大脑非常需要的营养蛋白质。 研究显示,在大脑中掌管记忆的海马回中含有特别丰富的 BDNF ,对于突触的生长以及长期记忆也非常重要。已经有许多国际研究显示,缺乏 BDNF 将可能造成一些认知障碍,例如阿兹海默症,此为常见的退化性失智症之一。
另外,若长期处于压力大或忧郁的状态,也可能会抑制大脑 BDNF 的分泌,影响记忆及认知功能,甚至于导致自律神经失调或海马回萎缩等更严重的问题。
注释
编辑- ^ Girotra P, Behl T, Sehgal A, Singh S, Bungau S. Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer's Disease. J Mol Neurosci. 2022 Feb;72(2):173-186. doi: 10.1007/s12031-021-01824-8. Epub 2021 Aug 23. PMID 34424488.
延伸阅读
编辑- Fawzi MH, Kira IA, Fawzi MM, Mohamed HE, Fawzi MM. Trauma profile in Egyptian adolescents with first-episode schizophrenia: relation to psychopathology and plasma brain-derived neurotrophic factor. J. Nerv. Ment. Dis. January 2013, 201 (1): 23–9. PMID 23274291. doi:10.1097/NMD.0b013e31827ab268.
- Vaynman S, Gomez-Pinilla F. Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J. Neurosci. Res. September 2006, 84 (4): 699–715. PMID 16862541. doi:10.1002/jnr.20979.
- van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U.S.A. November 1999, 96 (23): 13427–31. PMC 23964 . PMID 10557337.
- Gómez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. November 2002, 88 (5): 2187–95. PMID 12424260. doi:10.1152/jn.00152.2002.
- Meerwijk, Esther L., Judith M. Ford, and Sandra J. Weiss. Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain. Brain imaging and behavior. 2013, 7 (1): 1–14. PMID 12424260. doi:10.1007/s11682-012-9179-y.
外部链接
编辑- Cotman CW, Berchtold NC. BDNF and Alzheimer's Disease—What's the Connection?. Alzforum: Live Discussions. Alzheimer Research Forum. 2004-01-28 [2008-08-21]. (原始内容存档于2008-10-11).
- Patten-Hitt E. Brain-Derived Neurotrophic Factor (BDNF). Sciencexpress. The HDLighthouse, Huntingtons Disease: Information and Community. 2001-06-14 [2008-08-21]. (原始内容存档于2008-07-25).
- Highfield R. Brain scans 'could reveal mental strength'. Science. Telegraph.co.uk. 2007-10-18 [2008-08-21]. (原始内容存档于2008-05-31).
Low BDNF activity promotes resilience