白细胞介素-8

Interleukin 8
Interleukin 8
	PDB rendering based on 1IL8.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 3IL8
标识
代号	IL8; CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
扩展标识	遗传学：146930 同源基因：47937 ChEMBL: 2157 GeneCards: IL8 Gene
基因本体论描述
分子功能	· interleukin-8 receptor binding; · protein binding; · chemokine activity;
细胞成分	· extracellular region; · extracellular space;
生物过程	· angiogenesis; · response to molecule of bacterial origin; · cellular component movement; · inflammatory response; · immune response; · activation of signaling protein activity involved in unfolded protein response; · cell cycle arrest; · signal transduction; · G-protein coupled receptor signaling pathway; · negative regulation of cell proliferation; · calcium-mediated signaling; · regulation of cell adhesion; · neutrophil chemotaxis; · endoplasmic reticulum unfolded protein response; · receptor internalization; · response to endoplasmic reticulum stress; · intracellular signal transduction; · neutrophil activation; · cellular protein metabolic process; · cellular response to fibroblast growth factor stimulus; · regulation of retroviral genome replication; · negative regulation of G-protein coupled receptor protein signaling pathway; · embryonic digestive tract development; · induction of positive chemotaxis; · cellular response to lipopolysaccharide; · cellular response to interleukin-1; · cellular response to tumor necrosis factor; · positive regulation of neutrophil chemotaxis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	3576
Ensembl	ENSG00000169429
UniProt	P10145
mRNA序列	NM_000584
蛋白序列	NP_000575
基因位置	Chr 4:; 74.61 – 74.61 Mb
PubMed查询	[1]
	查; 论; 编;

白细胞介素-8（英语：Interleukin-8，简称为白介素-8或IL-8，亦称为趋化因子CXCL8）是巨噬细胞和上皮细胞等分泌的细胞因子^[1]。白细胞介素-8结合趋化因子受体白细胞介素-8受体α(IL8RA, 又叫CXCR1)和白细胞介素-8受体β(IL8RB, 又叫CXCR2)而对嗜中性粒细胞(neutrophils)有细胞趋化作用而实现其对炎症反应的调节^[2]^[1]。白细胞介素-8还有很强的促血管生成作用。白细胞介素-8在小支气管炎^[3] 和囊性纤维化^[4] 的发病中起重要作用。

参见

参考文献

^ ^1.0 ^1.1 Baggiolini, M.; Walz, A.; Kunkel, S. L. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84: 1045-1049, 1989.
^ Ahuja SK, Ozcelik T, Milatovitch A, Francke U, Murphy PM. Molecular evolution of the human interleukin-8 receptor gene cluster. Nat Genet. 1992 Sep;2(1):31-6.
^ Emi, M. et al., Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene. J. Hum. Genet. 44: 169-172, 1999.
^ Srivastava, M. et al., Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc. Nat. Acad. Sci. 101: 7693-7698, 2004.

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21. （页面存档备份，存于互联网档案馆）

[bag-1] 1.0 ^1.1 Baggiolini, M.; Walz, A.; Kunkel, S. L. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84: 1045-1049, 1989.

[ahu-2] Ahuja SK, Ozcelik T, Milatovitch A, Francke U, Murphy PM. Molecular evolution of the human interleukin-8 receptor gene cluster. Nat Genet. 1992 Sep;2(1):31-6.

[3] Emi, M. et al., Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene. J. Hum. Genet. 44: 169-172, 1999.

[4] Srivastava, M. et al., Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc. Nat. Acad. Sci. 101: 7693-7698, 2004.

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