司马尼布
化合物
司马尼布（INN：semaxanib；开发代号：SU5416）[1]是一种有机化合物，化学式为C15H14N2O。它可以2,4-二甲基吡咯为原料，经维尔斯迈尔-哈克反应转化为醛，再和羟吲哚缩合制得：[2][3][4]
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| CAS号 | 194413-58-6  |
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| 化学式 | C15H14N2O |
| 摩尔质量 | 238.29 g·mol−1 |
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参考文献
编辑- ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 85. WHO Drug Information. 2001, 15 (2). Full text (PDF). （原始内容 (PDF)存档于2007-03-16）. (244 KiB)
- ^ Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. Journal of Medicinal Chemistry. July 1998, 41 (14): 2588–2603. PMID 9651163. doi:10.1021/jm980123i.
- ^ Lubkoll J, Millemaggi A, Perry A, Taylor RJ. Tandem Horner–Wadsworth–Emmons/Heck procedures for the preparation of 3-alkenyl-oxindoles: The synthesis of Semaxanib and GW441756. Tetrahedron. 2010, 66 (33): 6606–6612. doi:10.1016/j.tet.2010.03.018.
- ^ Blanche EA, Maskell L, Colucci MA, Whatmore JL, Moody CJ. Synthesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles. Tetrahedron. 2009, 65 (25): 4894–4903. doi:10.1016/j.tet.2009.04.014.