奥昔布宁

奥昔布宁
临床资料
商品名（英语：Drug nomenclature）	Ditropan
AHFS/Drugs.com	Monograph
MedlinePlus	a682141
核准状况	欧 EMA: yes;
怀孕分级	澳: B1 ; ;
给药途径	口服给药、transdermal（英语：transdermal） gel、transdermal patch（英语：transdermal patch）
ATC码	G04BD04 (WHO) ;
法律规范状态
法律规范	澳：限医生处方（S4）; 加：处方药（℞-only）; 英：处方药（℞-only） (POM); 美：处方药（℞-only） and OTC;
药物动力学数据
血浆蛋白结合率	91–93%
生物半衰期	12.4–13.2 hours
识别信息
	IUPAC命名法 4-Diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylethanoate; ;
CAS号	5633-20-5
PubChem CID	4634;
IUPHAR/BPS	359;
DrugBank	DB01062 ;
ChemSpider	4473 ;
UNII	K9P6MC7092;
KEGG	D00465 ;
ChEBI	CHEBI:7856 ;
ChEMBL	ChEMBL1231 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0023406 ;
ECHA InfoCard	100.158.590
化学信息
化学式	C22H31NO3
摩尔质量	357.486 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(OCC#CCN(CC)CC)C(O)(c1ccccc1)C2CCCCC2;
	InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3 ; Key:XIQVNETUBQGFHX-UHFFFAOYSA-N ;

奥昔布宁（Oxybutynin），商品名Ditropan、Lyrinel XL、Lenditro (ZA)、Driptane (RU)、Uripan (Middle East)^[1]，为一种抗胆碱剂，可以缓解膀胱排尿困难，包含频尿及尿失禁等症状，可以降低膀胱肌肉痉挛^[2]。本品也可用于帮助缓解与肾结石相关的症状。

本品可竞争性拮抗M₁（英语：Muscarinic acetylcholine receptor M1）、M₂（英语：Muscarinic acetylcholine receptor M2），及M₃（英语：Muscarinic acetylcholine receptor M3）等蕈毒碱型乙酰胆碱受体。

本品可能也可用于治疗多汗症^[3]^[4]^[5]。

立体化学

奥昔布宁含有一个立体中心，由两种对映体组成。这是外消旋体，即1：（R）的1:1混合物 - 和（S）形式:^[6]^[7]

奥昔布宁的对映体
CAS-Nummer: 119618-21-2	CAS-Nummer: 119618-22-3

参考文献

^ Uripan Tablets. Adwia Pharmaceuticals. [22 November 2015]. （原始内容存档于2020-10-26）.
^ Chapple CR. "Muscarinic receptor antagonists in the treatment of overactive bladder". Urology (55)5, Supp. 1:33-46, 2000.
^ Tupker RA, Harmsze AM, Deneer VH. Oxybutynin therapy for generalized hyperhidrosis.. Arch Dermatol. 2006, 142 (8): 1065–6. PMID 16924061. doi:10.1001/archderm.142.8.1065.
^ Mijnhout GS, Kloosterman H, Simsek S, Strack van Schijndel RJ, Netelenbos JC. Oxybutynin: dry days for patients with hyperhidrosis.. Neth J Med. 2006, 64 (9): 326–8. PMID 17057269.
^ Schollhammer M, Misery L. Treatment of hyperhidrosis with oxybutynin.. Arch Dermatol. 2007, 143 (4): 544–5. PMID 17438194. doi:10.1001/archderm.143.4.544.
^ Kachur JF, et al. R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine, Journal of Pharmacology and Experimental Therapeutics, 247, S. 867–872, 1988; PMID 2849672.
^ Noronha-Blob L, Kachur JF. Enantiomers of oxybutynin: in vitro pharmacological characterization at M₁, M₂ and M₃ muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs, Journal of Pharmacology and Experimental Therapeutics, 256, S. 562–567, 1991; PMID 1993995.

外部链接

Template:Urologicals

Template:Muscarinic acetylcholine receptor modulators

[1] Uripan Tablets. Adwia Pharmaceuticals. [22 November 2015]. （原始内容存档于2020-10-26）.

[2] Chapple CR. "Muscarinic receptor antagonists in the treatment of overactive bladder". Urology (55)5, Supp. 1:33-46, 2000.

[3] Tupker RA, Harmsze AM, Deneer VH. Oxybutynin therapy for generalized hyperhidrosis.. Arch Dermatol. 2006, 142 (8): 1065–6. PMID 16924061. doi:10.1001/archderm.142.8.1065.

[4] Mijnhout GS, Kloosterman H, Simsek S, Strack van Schijndel RJ, Netelenbos JC. Oxybutynin: dry days for patients with hyperhidrosis.. Neth J Med. 2006, 64 (9): 326–8. PMID 17057269.

[5] Schollhammer M, Misery L. Treatment of hyperhidrosis with oxybutynin.. Arch Dermatol. 2007, 143 (4): 544–5. PMID 17438194. doi:10.1001/archderm.143.4.544.

[6] Kachur JF, et al. R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine, Journal of Pharmacology and Experimental Therapeutics, 247, S. 867–872, 1988; PMID 2849672.

[7] Noronha-Blob L, Kachur JF. Enantiomers of oxybutynin: in vitro pharmacological characterization at M₁, M₂ and M₃ muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs, Journal of Pharmacology and Experimental Therapeutics, 256, S. 562–567, 1991; PMID 1993995.

[1]

[2]

[3]

[4]

[5]

[6]

[7]