8-苯基茶碱

8-苯基茶碱
临床资料
ATC码	未分配;
识别信息
	IUPAC命名法 8-Phenyl-1,3-dimethyl-7H-purine-2,6-dione; ;
CAS号	961-45-5
PubChem CID	1922;
ChemSpider	1846 ;
UNII	E6M543P3BL;
ChEMBL	ChEMBL62350 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90242119 ;
化学信息
化学式	C13H12N4O2
摩尔质量	256.27 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Cn3c(=O)c2nc(c1ccccc1)[nH]c2n(C)c3=O;
	InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) ; Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N ;

8-苯基茶碱（英语：8-Phenyltheophylline，缩写8-PT，或称为8-苯基-1,3-二甲基黄嘌呤，8-phenyl-1,3-dimethylxanthine），分子式C₁₃H₁₂N₄O₂，是一种黄嘌呤衍生物，可作为腺苷受体 A₁和A_2A的选择性拮抗剂，但不具备磷酸二酯酶抑制药活性。^[1]^[2]^[3]

参考文献

^ Scotini E, Carpenedo F, Fassina G. New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacological Research Communications. February 1983, 15 (2): 131–43. PMID 6844374. doi:10.1016/s0031-6989(83)80055-1.
^ Rabe KF, Magnussen H, Dent G. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. The European Respiratory Journal. April 1995, 8 (4): 637–42. PMID 7664866. doi:10.1183/09031936.95.08040637.
^ Howell LL, Morse WH, Spealman RD. Respiratory effects of xanthines and adenosine analogs in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. September 1990, 254 (3): 786–91. PMID 2395111.

临床资料


ATC码	未分配
识别信息
IUPAC命名法 8-Phenyl-1,3-dimethyl-7H-purine-2,6-dione
CAS号	961-45-5 ^Y
PubChem CID	1922
ChemSpider	1846^Y
UNII	E6M543P3BL
ChEMBL	ChEMBL62350^Y
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90242119
化学信息
化学式	C₁₃H₁₂N₄O₂
摩尔质量	256.27 g·mol⁻¹
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES Cn3c(=O)c2nc(c1ccccc1)[nH]c2n(C)c3=O
InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15)^Y Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N^Y