降钙素
降钙素（英语：calcitonin）又称降钙激素、抑钙素[2]，是一种含有32个胺基酸的直线型多肽类激素，在人体里是由甲状腺的滤泡旁细胞（parafollicular cells，又称C细胞）制造。在鱼类、爬虫类、鸟类、哺乳类身上都有发现这种激素。降钙素主要功能是降低血钙，但其对于调节人体血液中钙离子的恒定通常并没有很显著的重要性。[3]
| Calcitonin/calcitonin-related polypeptide, alpha | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; MGC126648 | ||||||||||||
| 扩展标识 | 遗传学：114130 鼠基因：2151253 同源基因：1319 GeneCards: CALCA Gene | ||||||||||||
| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 796 | 12310 | |||||||||||
| Ensembl | ENSG00000110680 | ENSMUSG00000030669 | |||||||||||
| UniProt | P01258 | Q99JA0 | |||||||||||
| mRNA序列 | NM_001033952 | NM_001033954 | |||||||||||
| 蛋白序列 | NP_001029124 | NP_001029126 | |||||||||||
| 基因位置 |
Chr 11: 14.94 – 14.95 Mb |
Chr 7: 114.42 – 114.43 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
主要作用
编辑降钙素影响了钙离子和磷酸盐的代谢过程，其功能多半是拮抗副甲状腺素的作用。[4]
降钙素主要透过下列四种方式降低血钙浓度：
分泌
编辑刺激降钙素分泌的因素：
- 血浆中钙离子浓度过高[8]
参考资料
编辑- ^ PDB 2glhAndreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A. Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix. J. Biol. Chem. August 2006, 281 (34): 24193–203. PMID 16766525. doi:10.1074/jbc.M603528200.
- ^ 存档副本. [2022-11-27]. （原始内容存档于2022-11-27）.
- ^ Costoff A. Sect. 5, Ch. 6: Biological Actions of CT. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-07-05）.
- ^ Boron WF, Boulpaep EL. Endocrine system chapter. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. 2004. ISBN 1-4160-2328-3.
- ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on the Small Intestine. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-10-06）.
- ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on Bone. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-06-22）.
- ^ 7.0 7.1 Carney SL. Calcitonin and human renal calcium and electrolyte transport. Miner Electrolyte Metab. 1997, 23 (1): 43–7. PMID 9058369.
- ^ Costanzo, Linda S. BRS Physiology. Lippincott, Williams, & Wilkins. 2007: 263 [2010-10-23]. ISBN 978-0781773119. （原始内容存档于2010-09-25）.
- ^ Erdogan MF, Gursoy A, Kulaksizoglu M. Long-term effects of elevated gastrin levels on calcitonin secretion. J Endocrinol Invest. October 2006, 29 (9): 771–775. PMID 17114906. （原始内容存档于2016-05-15）.
延伸阅读
编辑- MacIntyre I, Alevizaki M, Bevis PJ, Zaidi M. Calcitonin and the peptides from the calcitonin gene. Clinical Orthopaedics and Related Research. April 1987, (217): 45–55. PMID 3549095. doi:10.1097/00003086-198704000-00007.
- Di Angelantonio S, Giniatullin R, Costa V, Sokolova E, Nistri A. Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. British Journal of Pharmacology. July 2003, 139 (6): 1061–73. PMC 1573932
. PMID 12871824. doi:10.1038/sj.bjp.0705337. - Findlay DM, Sexton PM. Calcitonin. Growth Factors. December 2004, 22 (4): 217–24. PMID 15621724. doi:10.1080/08977190410001728033.
- Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Critical Care. 2007, 10 (5): R145. PMC 1751067 . PMID 17038199. doi:10.1186/cc5067.
- Schneider HG, Lam QT. Procalcitonin for the clinical laboratory: a review. Pathology. August 2007, 39 (4): 383–90. PMID 17676478. doi:10.1080/00313020701444564.
- Grani G, Nesca A, Del Sordo M, Calvanese A, Carbotta G, Bianchini M, Fumarola A. Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis. Endocrine-Related Cancer (Bioscientifica). June 2012, 19 (3): 345–9. PMID 22399011. doi:10.1530/ERC-12-0013.
