蘇馬尼羅

化合物

蘇馬尼羅(英語:Sumanirole,研發代號:PNU-95,666)是一種有機化合物,化學式C11H13N3O,能作為多巴胺受體D2的選擇性完全激動劑[1],1997年為帕金森氏病不寧腿綜合症研發[2][3]

蘇馬尼羅
臨床資料
其他名稱PNU-95,666
ATC碼
  • 未分配
識別資訊
  • (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one
CAS號179386-43-7
179386-44-8 (maleate))
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C11H13N3O
摩爾質量203.25 g·mol−1
3D模型(JSmol英語JSmol
  • CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23

參考文獻

編輯
  1. ^ McCall RB, Lookingland KJ, Bédard PJ, Huff RM. Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. September 2005, 314 (3): 1248–56. PMID 15980060. S2CID 9835081. doi:10.1124/jpet.105.084202. 
  2. ^ Romero AG, et al. Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy. Journal of Organic Chemistry. 1997; 62(19):6582.
  3. ^ Weber M, Chang WL, Breier MR, Yang A, Millan MJ, Swerdlow NR. The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats. European Neuropsychopharmacology. March 2010, 20 (6): 421–425. PMC 2864324 . PMID 20346635. doi:10.1016/j.euroneuro.2010.02.011.