TAS2R31
位於12號人類染色體的基因
味覺感受器，類型2，成員31，TAS2R31 是一個人類基因組中TAS2R31基因編碼的蛋白質，是苦味味覺感受器的一員。[1]這個苦味感受器已被證明在體外可與糖精起反應。[2]
| 味覺感受器，類型2，成員31 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 標識 | |||||||||||||
| 代號 | TAS2R31; T2R31; T2R44; T2R53; TAS2R44 | ||||||||||||
| 擴展標識 | 遺傳學：612669 鼠基因：2681304 同源基因：89249 IUPHAR: GeneCards: TAS2R31 Gene | ||||||||||||
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| 直系同源體 | |||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||
| Entrez | 259290 | 353165 | |||||||||||
| Ensembl | ENSG00000256436 | ENSMUSG00000053217 | |||||||||||
| UniProt | P59538 | Q7TQA8 | |||||||||||
| mRNA序列 | NM_176885 | NM_181276.1 | |||||||||||
| 蛋白序列 | NP_795366 | NP_851793.1 | |||||||||||
| 基因位置 |
Chr 12: 11.18 – 11.18 Mb |
Chr 6: 132.73 – 132.73 Mb | |||||||||||
| PubMed查詢 | [1] | [2] | |||||||||||
TAS2R31和其它幾種苦味感受器也在人類呼吸道平滑肌細胞上表達。它們在這些細胞中的活化會導致細胞內鈣離子增加，從而觸發鉀離子通道打開，使細胞膜超極化，平滑肌放鬆。因此，這些受體的活化會導致支氣管擴張。[3]
該基因的多態性也與甜味劑安賽蜜的苦味感有關。(PMID 23599216)
另見
編輯參考文獻
編輯- ^ Entrez Gene: TAS2R31 taste receptor, type 2, member 31.
- ^ Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W. Bitter taste receptors for saccharin and acesulfame K. J. Neurosci. November 2004, 24 (45): 10260–5. PMID 15537898. doi:10.1523/JNEUROSCI.1225-04.2004.
- ^ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. November 2010, 16 (11): 1299–304. PMC 3066567
. PMID 20972434. doi:10.1038/nm.2237.
延伸閱讀
編輯- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Bufe B, Hofmann T, Krautwurst D; et al. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.. Nat. Genet. 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Conte C, Ebeling M, Marcuz A; et al. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
- Pronin AN, Tang H, Connor J, Keung W. Identification of ligands for two human bitter T2R receptors.. Chem. Senses. 2005, 29 (7): 583–93. PMID 15337684. doi:10.1093/chemse/bjh064.
- Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Kuhn C, Bufe B, Winnig M; et al. Bitter taste receptors for saccharin and acesulfame K.. J. Neurosci. 2005, 24 (45): 10260–5. PMID 15537898. doi:10.1523/JNEUROSCI.1225-04.2004.