免疫相關GTP酶家族M蛋白

免疫相關GTP酶家族M蛋白（英語：Immunity-related GTPase family M protein，IRGM），亦稱為干擾素誘導蛋白1（英語：interferon-inducible protein 1，IFI1），是人體IRGM基因表達的一種酶。

免疫相關GTP酶家族M蛋白
識別號
別名	IRGM；, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M
外部ID	OMIM：608212 MGI：1926262 HomoloGene：78363 GeneCards：IRGM
相關疾病
inflammatory bowel disease 19
基因位置（人類） 染色體 5號染色體 基因座 5q33.1 起始 150,846,521 bp 終止 150,900,736 bp
基因位置（小鼠） 染色體 小鼠11號染色體 基因座 11|11 B1.3 起始 58,090,444 bp 終止 58,113,608 bp
基因本體 分子功能 • 核苷酸結合 • GTP binding • 水解酶活性 • 血漿蛋白結合 • protein kinase binding • protein serine/threonine kinase activator activity • CARD domain binding • BH3 domain binding • GTPase activity 細胞組分 • phagocytic vesicle membrane • autophagosome membrane • cell projection • phagocytic cup • 細胞膜 • 膜 • cytoplasmic vesicle • Golgi membrane • 線粒體 • 高爾基體 • 細胞質基質 • endoplasmic reticulum membrane 生物學過程 • 自噬 • inflammatory response • immune system process • autophagosome assembly • positive regulation of protein phosphorylation • positive regulation of autophagy • positive regulation of peptidyl-threonine phosphorylation • protein destabilization • positive regulation of peptidyl-serine phosphorylation • regulation of protein-containing complex assembly • 先天免疫系統 • protein stabilization • defense response to Gram-negative bacterium • positive regulation of interferon-gamma-mediated signaling pathway • regulation of protein complex stability • protein lipidation involved in autophagosome assembly • CAMKK-AMPK signaling cascade • nucleotide-binding oligomerization domain containing 2 signaling pathway • cellular response to lipopolysaccharide • positive regulation of autophagosome maturation • positive regulation of protein serine/threonine kinase activity • defense response • cellular response to interferon-beta Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	345611	54396
Ensembl	ENSG00000237693	ENSMUSG00000069874
UniProt	A1A4Y4	Q9Z1M2
mRNA​序列	NM_001145805 ​NM_001346557	NM_019440
蛋白序列	NP_001139277 ​NP_001333486	無數據
基因位置​（UCSC）	Chr 5: 150.85 – 150.9 Mb	Chr 11: 58.09 – 58.11 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

IRGM是干擾素誘導GTP酶家族中的分子量為47kDa的免疫相關鳥苷三磷酸酶（IRGs）成員之一。該基因編碼的蛋白可能通過調控對胞內病原體的自噬形成而在先天免疫反應中發揮重要作用。

臨床意義

影響該基因表達的多態性位點與克隆氏症和結核病的易感性有關。

深入閱讀

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免疫相關GTP酶家族M蛋白引用了美國國家醫學圖書館提供的數據，這些數據屬於公共領域。