黑素皮質素受體1

MC1R 基因
識別號
別名	MC1R；, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
外部ID	OMIM：155555 MGI：99456 HomoloGene：1789 GeneCards：MC1R
相關疾病
	skin carcinoma、基底細胞癌（BCC）
為以下藥物的標靶
	美拉諾坦 I、美拉諾坦 II
基因位置（人類）
染色體	16號染色體
終止	89,920,973 bp
基因位置（小鼠）
染色體	小鼠8號染色體
終止	124,137,483 bp
基因本體
分子功能	• G protein-coupled peptide receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • melanocyte-stimulating hormone receptor activity; • 血漿蛋白結合; • melanocortin receptor activity; • 泛素蛋白連接酶結合;
細胞組分	• integral component of membrane; • 膜; • 細胞膜; • integral component of plasma membrane; • 胞內;
生物學過程	• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • multicellular organism development; • UV protection; • 腫瘤壞死因子產生的負調控; • UV-damage excision repair; • 信號轉導; • positive regulation of protein kinase A signaling; • intracellular signal transduction; • 色素沉着; • positive regulation of transcription by RNA polymerase II; • positive regulation of protein kinase B signaling; • positive regulation of protein kinase C signaling; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • 痛覺; • melanin biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	4157
	17199
	ENSG00000258839
	ENSMUSG00000074037
	Q01726
	Q01727
	NM_002386
	NM_008559
	NP_002377
	NP_032585
	維基數據
檢視/編輯人類	檢視/編輯小鼠

黑素皮質素受體1 (MC1R)是一種G蛋白耦合受體，長度約為310個氨基酸左右，其基因序列只有一個外顯子, 有7個跨膜結構域, 是最小的G蛋白耦合受體^[7]。

MC1R是參與調節動物皮膚和毛髮顏色的關鍵蛋白質之一。 MC1R基因的變異可引起動物黑色素形成的變化及毛色的變異。^[8]

參考文獻

^ 與MC1R 基因相關的疾病；在維基數據上查看/編輯參考.
^ 對MC1R 基因起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000258839 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000074037 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ren, Gang; Li, En; Zhao, Shiye; Jiang, Yanqiong; Wang, Shasha; Tang, Sixian; Hu, Huijian. Correlation between color polymorphism and the MC1R gene of Lanius schach. Biodiversity Science. 2020-06-20, 28 (6): 688. doi:10.17520/biods.2019307.
^ 董飈; 秦豪榮,徐琪,李曉鳴,紀榮超,王健. 番鸭MC1R基因多态性与羽毛相关性分析. 江蘇農業科學. 2017, 45 (10): 24–27 [2020-12-15].

外部連結

Melanocortin Receptors: MC₁. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2020-12-16]. （原始內容存檔於2021-01-28）.
醫學主題詞表（MeSH）：Melanocortin+Receptor+1

[1] 與MC1R 基因相關的疾病；在維基數據上查看/編輯參考.

[2] 對MC1R 基因起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000258839 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000074037 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[7] Ren, Gang; Li, En; Zhao, Shiye; Jiang, Yanqiong; Wang, Shasha; Tang, Sixian; Hu, Huijian. Correlation between color polymorphism and the MC1R gene of Lanius schach. Biodiversity Science. 2020-06-20, 28 (6): 688. doi:10.17520/biods.2019307.

[8] 董飈; 秦豪榮,徐琪,李曉鳴,紀榮超,王健. 番鸭MC1R基因多态性与羽毛相关性分析. 江蘇農業科學. 2017, 45 (10): 24–27 [2020-12-15].

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