脂筏模型

生物膜的脂筏模型（英文：lipid rafts model），由凱伊·西蒙斯（英語：Kai Simons）和格里特·范梅爾（Gerrit van Meer）提出，是指在磷脂雙分子層上，膽固醇、鞘磷脂等富集區域形成相對有序的脂相，如同漂浮在脂雙層上的「脂筏」載着執行特定生物學功能膜蛋白^[1]^[2]^[3]。這些區域比膜的其他部分厚，更有秩序且流動性相較於周圍較小。其周圍是流動性較高的液態區。脂筏參與訊號轉導、受體介導的內吞作用以及膽固醇代謝運輸等。脂笩功能的紊亂會引發多種疾病。

參考文獻

^ Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D. Analysis of lipid rafts in T cells. Molecular Immunology. 2004, 41 (4): 399–409. PMID 15163537. doi:10.1016/j.molimm.2004.03.022.
^ Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. Role of lipid rafts in T cells. Archivum Immunologiae et Therapiae Experimentalis. 2004, 52 (4): 215–24 [2020-04-10]. PMID 15467486. （原始內容存檔於2017-10-06）.
^ Korade, Zeljka; Kenworthy, Anne K. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008, 55 (8): 1265–73. PMC 2638588  . PMID 18402986. doi:10.1016/j.neuropharm.2008.02.019.

書籍

吳光耀主編：《精英教案》，軍事宜文出版社，2005

擴展閱讀

Simons K, van Meer G (August 1988). "Lipid sorting in epithelial cells". Biochemistry, 27 (17): 6197–202.
Simons K, Ikonen E (June 1997). "Functional rafts in cell membranes". Nature,387 (6633): 569–72.

[Thomas2004-1] Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D. Analysis of lipid rafts in T cells. Molecular Immunology. 2004, 41 (4): 399–409. PMID 15163537. doi:10.1016/j.molimm.2004.03.022.

[2] Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. Role of lipid rafts in T cells. Archivum Immunologiae et Therapiae Experimentalis. 2004, 52 (4): 215–24 [2020-04-10]. PMID 15467486. （原始內容存檔於2017-10-06）.

[korade-3] Korade, Zeljka; Kenworthy, Anne K. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008, 55 (8): 1265–73. PMC 2638588  . PMID 18402986. doi:10.1016/j.neuropharm.2008.02.019.

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