脂筏模型

生物膜的脂筏模型（英文：lipid rafts model），由凯伊·西蒙斯（英语：Kai Simons）和格里特·范梅尔（Gerrit van Meer）提出，是指在磷脂双分子层上，胆固醇、鞘磷脂等富集区域形成相对有序的脂相，如同漂浮在脂双层上的“脂筏”载着执行特定生物学功能膜蛋白^[1]^[2]^[3]。这些区域比膜的其他部分厚，更有秩序且流动性相较于周围较小。其周围是流动性较高的液态区。脂筏参与讯号转导、受体介导的内吞作用以及胆固醇代谢运输等。脂笩功能的紊乱会引发多种疾病。

参考文献

^ Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D. Analysis of lipid rafts in T cells. Molecular Immunology. 2004, 41 (4): 399–409. PMID 15163537. doi:10.1016/j.molimm.2004.03.022.
^ Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. Role of lipid rafts in T cells. Archivum Immunologiae et Therapiae Experimentalis. 2004, 52 (4): 215–24 [2020-04-10]. PMID 15467486. （原始内容存档于2017-10-06）.
^ Korade, Zeljka; Kenworthy, Anne K. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008, 55 (8): 1265–73. PMC 2638588  . PMID 18402986. doi:10.1016/j.neuropharm.2008.02.019.

书籍

吴光耀主编：《精英教案》，军事宜文出版社，2005

扩展阅读

Simons K, van Meer G (August 1988). "Lipid sorting in epithelial cells". Biochemistry, 27 (17): 6197–202.
Simons K, Ikonen E (June 1997). "Functional rafts in cell membranes". Nature,387 (6633): 569–72.

[Thomas2004-1] Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D. Analysis of lipid rafts in T cells. Molecular Immunology. 2004, 41 (4): 399–409. PMID 15163537. doi:10.1016/j.molimm.2004.03.022.

[2] Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. Role of lipid rafts in T cells. Archivum Immunologiae et Therapiae Experimentalis. 2004, 52 (4): 215–24 [2020-04-10]. PMID 15467486. （原始内容存档于2017-10-06）.

[korade-3] Korade, Zeljka; Kenworthy, Anne K. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008, 55 (8): 1265–73. PMC 2638588  . PMID 18402986. doi:10.1016/j.neuropharm.2008.02.019.

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