達爾奈多INN:dalzanemdor;開發代號:SAGE-718)是一種正在研究用於治療神經系統疾病和認知障礙的實驗性藥物,[1]神經甾體英語neurosteroid腦甾醇的類似物。[2]截至2022年,它在阿茲海默症[3][4][5]柏金遜症亨丁頓舞蹈症[6][7]的治療上處於二期臨床研究階段

達爾奈多
INN dalzanemdor
臨床資料
其他名稱SAGE-718
法律規範狀態
法律規範
  • Investigational
識別資訊
  • (3S,8R,9S,10R,13R,14S,17R)-3,13-Dimethyl-17-[(2R,5S)-6,6,6-trifluoro-5-hydroxy-5-methylhexan-2-yl]-2,4,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS號2311911-06-3  checkY
PubChem CID
KEGG
ChEMBL
化學資訊
化學式C26H41F3O2
摩爾質量442.61 g·mol−1
3D模型(JSmol英語JSmol
  • C[C@H](CC[C@@](C)(C(F)(F)F)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@H]3CC[C@](C4)(C)O)C
  • InChI=InChI=1S/C26H41F3O2/c1-16(9-14-25(4,31)26(27,28)29)21-7-8-22-20-6-5-17-15-23(2,30)12-10-18(17)19(20)11-13-24(21,22)3/h5,16,18-22,30-31H,6-15H2,1-4H3/t16-,18+,19-,20-,21-,22+,23+,24-,25+/m1/s1
  • Key:RTBRKGVJBGKMFF-YMEFNWBESA-N

參考文獻

編輯
  1. ^ Hill MD, Blanco MJ, Salituro FG, Bai Z, Beckley JT, Ackley MA, et al. SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment. Journal of Medicinal Chemistry. July 2022, 65 (13): 9063–9075. PMID 35785990. S2CID 250250073. doi:10.1021/acs.jmedchem.2c00313. 
  2. ^ SAGE-718. ALZFORUM. 
  3. ^ Shapiro L. #AAN2022 – SAGE-718 May Help With Cognitive Function in Alzheimer's. BioNews, Inc. 2022-04-05. 
  4. ^ SAGE-718 in Patients With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease: Results From the Phase 2 LUMINARY Study (PDF). American Academy of Neurology (AAN) 74th Annual Meeting Abstract. 
  5. ^ Castañeda R. Regulatory roundup: Sage Alzheimer's asset likely to progress after Phase IIa completion. Clinical Trials Arena. 2021-11-16 [2022-07-13]. (原始內容存檔於2022-05-28). 
  6. ^ Sage Therapeutics Provides Important Update On The Clinical Development Program For Sage's Investigational Drug, SAGE-718.. Huntington's Disease Society of America. 2022-02-22. 
  7. ^ Wexler M. SAGE-718 on FDA Fast Track as Potential Huntington's Disease Therapy. BioNews, Inc. 2021-09-21. 

外部連結

編輯