ABT-418

ABT-418
識別資訊
	IUPAC命名法 3-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole; ;
CAS號	147402-53-7
PubChem CID	119380;
ChemSpider	106627 ;
UNII	B9I6MZL7BW;
ChEMBL	ChEMBL274525 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID10163711 ;
化學資訊
化學式	C9H14N2O
摩爾質量	166.22
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CC1=NOC(=C1)[C@@H]2CCCN2C;
	InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 ; Key:ILLGYRJAYAAAEW-QMMMGPOBSA-N ;

ABT-418是一種有機化合物，化學式為C₉H₁₄N₂O，由美國雅培開發，可用作益智藥和抗焦慮藥。^[1]^[2]^[3]^[4]^[5]

參考文獻

^ Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09]. PMID 7518514. （原始內容存檔於2005-05-07）.
^ Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09]. PMID 7913497. （原始內容存檔於2005-05-07）.
^ Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09]. PMID 7965735. （原始內容存檔於2009-09-05）.
^ Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363. S2CID 34377165. doi:10.1007/s002130050240.
^ Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609. doi:10.1016/j.ejmech.2010.09.009.

外部連結

[pmid7518514-1] Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09]. PMID 7518514. （原始內容存檔於2005-05-07）.

[pmid7913497-2] Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09]. PMID 7913497. （原始內容存檔於2005-05-07）.

[pmid7965735-3] Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09]. PMID 7965735. （原始內容存檔於2009-09-05）.

[pmid9151363-4] Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363. S2CID 34377165. doi:10.1007/s002130050240.

[5] Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609. doi:10.1016/j.ejmech.2010.09.009.

[1]

[2]

[3]

[4]

[5]

識別資訊

IUPAC命名法 3-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole
CAS號	147402-53-7 ^Y
PubChem CID	119380
ChemSpider	106627^Y
UNII	B9I6MZL7BW
ChEMBL	ChEMBL274525^Y
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID10163711
化學資訊
化學式	C₉H₁₄N₂O
摩爾質量	166.22
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES CC1=NOC(=C1)[C@@H]2CCCN2C
InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1^Y Key:ILLGYRJAYAAAEW-QMMMGPOBSA-N^Y