DPH-362是一種含氮有機化合物,分子式C18H21N,與阿米替林三環類抗抑鬱藥(TCA)類似,但其中的二苯並環庚烯變為了二苯甲烷[1][2],衍生物有SKF-89976A

DPH-362
臨床資料
其他名稱PD129167
識別資訊
  • N,N-dimethyl-4,4-diphenylbut-3-en-1-amine
CAS號28916-83-8
PubChem CID
ChemSpider
化學資訊
化學式C18H21N
摩爾質量251.37 g·mol−1
3D模型(JSmol英語JSmol
  • CN(C)CCC=C(C1=CC=CC=C1)C2=CC=CC=C2
  • InChI=InChI=1S/C18H21N/c1-19(2)15-9-14-18(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-14H,9,15H2,1-2H3
  • Key:ZRPJJBLGKLVADE-UHFFFAOYSA-N

參考文獻

編輯
  1. ^ Bölcskei H, Tarnawa I, Kocsis P. Voltage-gated sodium channel blockers, 2001-2006: An overview.. Medicinal Chemistry Research. June 2008, 17 (2–7): 356–368. doi:10.1007/s00044-007-9071-2. 
  2. ^ Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2. Bioorganic & Medicinal Chemistry. December 2006, 14 (24): 8366–8378. PMC 2756728 . PMID 17035036. doi:10.1016/j.bmc.2006.09.010.