DPH-362是一种含氮有机化合物,分子式C18H21N,与阿米替林三环类抗抑郁药(TCA)类似,但其中的二苯并环庚烯变为了二苯甲烷[1][2],衍生物有SKF-89976A

DPH-362
临床资料
其他名称PD129167
识别信息
  • N,N-dimethyl-4,4-diphenylbut-3-en-1-amine
CAS号28916-83-8
PubChem CID
ChemSpider
化学信息
化学式C18H21N
摩尔质量251.37 g·mol−1
3D模型(JSmol英语JSmol
  • CN(C)CCC=C(C1=CC=CC=C1)C2=CC=CC=C2
  • InChI=InChI=1S/C18H21N/c1-19(2)15-9-14-18(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-14H,9,15H2,1-2H3
  • Key:ZRPJJBLGKLVADE-UHFFFAOYSA-N

参考文献

编辑
  1. ^ Bölcskei H, Tarnawa I, Kocsis P. Voltage-gated sodium channel blockers, 2001-2006: An overview.. Medicinal Chemistry Research. June 2008, 17 (2–7): 356–368. doi:10.1007/s00044-007-9071-2. 
  2. ^ Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2. Bioorganic & Medicinal Chemistry. December 2006, 14 (24): 8366–8378. PMC 2756728 . PMID 17035036. doi:10.1016/j.bmc.2006.09.010.