HMOX1

血红素加氧酶1（英语：heme oxygenase 1，缩写HMOX1或HO-1）是一种血红素加氧酶（EC 1.14.99.3），是血红素代谢过程中的重要酶，它将血红素转化为胆绿素。

Heme oxygenase (decycling) 1 血红素加氧酶1（脱环）
PDB rendering based on 1n3u.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM
标识
代号	HMOX1; HMOX1D; HO-1; HSP32; bK286B10
扩展标识	遗传学：141250 鼠基因：96163 同源基因：31075 ChEMBL: 2823 GeneCards: HMOX1 Gene
EC编号	1.14.99.3
基因本体论描述 分子功能 · heme oxygenase (decyclizing) activity · phospholipase D activity · signal transducer activity · enzyme binding · heme binding · protein homodimerization activity · metal ion binding 细胞成分 · extracellular space · nucleus · nucleolus · endoplasmic reticulum · endoplasmic reticulum membrane · cytosol · caveola · membrane 生物过程 · angiogenesis · endothelial cell proliferation · wound healing involved in inflammatory response · negative regulation of leukocyte migration · porphyrin-containing compound metabolic process · heme oxidation · cellular iron ion homeostasis · response to oxidative stress · intracellular protein kinase cascade · small GTPase mediated signal transduction · excretion · regulation of blood pressure · cell death · intrinsic apoptotic signaling pathway in response to DNA damage · smooth muscle hyperplasia · cellular response to nutrient · negative regulation of mast cell cytokine production · erythrocyte homeostasis · low-density lipoprotein particle clearance · response to nicotine · heme catabolic process · response to hydrogen peroxide · negative regulation of apoptotic process · positive regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of mast cell degranulation · negative regulation of DNA binding · negative regulation of sequence-specific DNA binding transcription factor activity · negative regulation of neuron apoptotic process · regulation of transcription from RNA polymerase II promoter in response to oxidative stress · response to estrogen stimulus · small molecule metabolic process · positive regulation of chemokine biosynthetic process · regulation of angiogenesis · positive regulation of angiogenesis · positive regulation of vasodilation · positive regulation of smooth muscle cell proliferation · negative regulation of smooth muscle cell proliferation · regulation of sequence-specific DNA binding transcription factor activity · protein homooligomerization · iron ion homeostasis · transmembrane transport · cellular response to cadmium ion · cellular response to hypoxia Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
mRNA序列	NM_002133	NM_010442
蛋白序列	NP_002124	NP_034572
基因位置	Chr 22: 35.78 – 35.79 Mb	Chr 8: 75.09 – 75.1 Mb
PubMed查询	[1]	[2]

另见

• HMOX2

延伸阅读

• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858 . PMID 9884342. doi:10.1172/JCI4165. 
• Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147 . PMID 17525142. doi:10.1093/brain/awm095. 
• Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x. 
• Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862. 
• Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x. 
• Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767. 
• Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008. 
• Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630. 
• Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894. 
• Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093.