白桦脂酸(英语:Betulinic acid,也称作白桦酯酸桦木酸表白桦脂酸)是一种天然的羽扇豆烷型五环三萜化合物,具有抗逆转录病毒活性,抗疟疾活性和抗炎活性,最近又有报道称能通过抑制拓扑异构酶而具有抗癌活性[1],最早发现于桦木属的一些物种,如毛桦Betula pubescens)的树皮[2]因而得名。

白桦脂酸
IUPAC名
(3β)-3-Hydroxy-lup-20(29)-en-28-oic acid
系统名
(1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,2,14,18,18-hexamethyl-8-(1-methylethenyl)pentacyclo[11.8.0.02,10.05,9.014,19]henicosane-5-carboxylic acid

(1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-1,2,14,18,18-五甲基-8-(1-甲基乙烯基)-17-羟基五环[11.8.0.02,10.05,9.014,19]二十一烷-5-甲酸

别名 白桦酯酸
桦木酸
表白桦脂酸
识别
CAS号 472-15-1  checkY
PubChem 64971
ChemSpider 58496
SMILES
 
  • O=C(O)[C@@]54[C@@H]([C@@H]3[C@@]([C@]1([C@@H]([C@]2(C)[C@@H](CC1)C(C)(C)[C@@H](O)CC2)CC3)C)(C)CC4)[C@H](C(=C)C)CC5
InChI
 
  • 1/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
InChIKey QGJZLNKBHJESQX-FZFNOLFKBI
EINECS 207-448-8
ChEBI 3087
IUPHAR配体 3945
性质
化学式 C30H48O3
摩尔质量 456.7 g·mol−1
熔点 316-318 °C(589-591 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

另见

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参考文献

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  1. ^ Chowdhury AR, Mandal S, Mittra B, Sharma S, Mukhopadhyay S, Majumder HK. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical Science Monitor. July 2002, 8 (7): BR254–65. PMID 12118187. 
  2. ^ Tan Y, Yu R, Pezzuto JM. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clinical Cancer Research. July 2003, 9 (7): 2866–75 [2019-11-23]. PMID 12855667. (原始内容存档于2013-02-23).