肽聚糖识别蛋白

肽聚糖识别蛋白（英语：Peptidoglycan recognition proteins，PGRPs）是一类高度保守的模式识别受体，至少含有一个肽聚糖识别结构域，可识别细菌细胞壁的肽聚糖，在昆虫、软体动物、棘皮动物和脊索动物中都有存在。不同生物类群的PGRPs起的效应不同，在昆虫中，PGRPs激活Toll等多个通路来启动吞噬作用杀死细菌^[1]^[2]。在哺乳动物中，PGRPs通过与细菌细胞壁的肽聚糖相互作用来杀死细菌^[2]。

参考文献

^ Royet, Julien; Gupta, Dipika; Dziarski, Roman. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nature Reviews Immunology. 11 November 2011, 11: 837–51. PMID 22076558. doi:10.1038/nri3089.
^ ^2.0 ^2.1 Dziarski, R. Peptidoglycan recognition proteins (PGRPs). Molecular Immunology. February 2004, 40 (12): 877–886. doi:10.1016/j.molimm.2003.10.011.

[D2011-1] Royet, Julien; Gupta, Dipika; Dziarski, Roman. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nature Reviews Immunology. 11 November 2011, 11: 837–51. PMID 22076558. doi:10.1038/nri3089.

[D2004-2] 2.0 ^2.1 Dziarski, R. Peptidoglycan recognition proteins (PGRPs). Molecular Immunology. February 2004, 40 (12): 877–886. doi:10.1016/j.molimm.2003.10.011.

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