阿维扎封

阿维扎封
临床资料
给药途径	肌肉注射
ATC码	未分配;
识别信息
	IUPAC命名法 (2S)-2,6-diamino-N-{[(2-benzoyl-4-chlorophenyl)methylcarbamoyl]methyl}hexanamide; ;
CAS号	65617-86-9
PubChem CID	71968;
ChemSpider	64974 ;
UNII	65NK71K78P;
ChEMBL	ChEMBL2103985 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90215868 ;
化学信息
化学式	C22H27ClN4O3
摩尔质量	430.93 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Clc1cc(c(N(C(=O)CNC(=O)[C@@H](N)CCCCN)C)cc1)C(=O)c2ccccc2;
	InChI InChI=1S/C22H27ClN4O3/c1-27(20(28)14-26-22(30)18(25)9-5-6-12-24)19-11-10-16(23)13-17(19)21(29)15-7-3-2-4-8-15/h2-4,7-8,10-11,13,18H,5-6,9,12,14,24-25H2,1H3,(H,26,30)/t18-/m0/s1 ; Key:LTKOVYBBGBGKTA-SFHVURJKSA-N ;

阿维扎封（英语：Avizafone^[1]或Pro-Diazepam）是苯二氮䓬衍生物地西泮的水溶性前药。它可以用于肌肉内给药。

阿维扎封被血液中的酶代谢形成活性药物地西泮。主要用作有机磷类神经毒剂中毒的解毒剂。^[2]^[3]^[4]

参见

^ GB 1517164
^ Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A. On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig. The Journal of Pharmacy and Pharmacology. April 1990, 42 (4): 247–51. PMID 1974291. S2CID 32369013. doi:10.1111/j.2042-7158.1990.tb05401.x.
^ Lallement G, Renault F, Baubichon D, Peoc'h M, Burckhart MF, Galonnier M, et al. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Archives of Toxicology. October 2000, 74 (8): 480–6. PMID 11097386. S2CID 22292597. doi:10.1007/s002040000146.
^ Taysse L, Calvet JH, Buée J, Christin D, Delamanche S, Breton P. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose. Toxicology. June 2003, 188 (2–3): 197–209. PMID 12767691. doi:10.1016/s0300-483x(03)00086-6.