阿达色林
化合物
阿达色林（INN：adatanserin；开发代号：WY-50,324、SEB-324）是一种混合的5-HT1A受体部分激动剂以及5-HT2A和5-HT2C受体拮抗剂。[1][2][3]惠氏公司试图将其开发为抗抑郁药，但最终没有得到推广。[3][4]
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| CAS号 | 127266-56-2  |
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| 化学式 | C21H31N5O |
| 摩尔质量 | 369.51 g·mol−1 |
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参见
编辑参考资料
编辑- ^ Singh A, Lucki I. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. April 1993, 32 (4): 331–40. PMID 8497336. S2CID 38611829. doi:10.1016/0028-3908(93)90153-T.
- ^ Kleven MS, Koek W. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. The Journal of Pharmacology and Experimental Therapeutics. February 1996, 276 (2): 388–97. PMID 8632301.
- ^ 3.0 3.1 Abou-Gharbia MA, Childers WE, Fletcher H, et al. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. Journal of Medicinal Chemistry. December 1999, 42 (25): 5077–94. PMID 10602693. doi:10.1021/jm9806704.
- ^ Stahl, S. M. Essential psychopharmacology: neuroscientific basis and practical application
. Cambridge, UK: Cambridge University Press. 2000: 262. ISBN 0-521-64615-4. adatanserin.
- ^ Dawson LA, Galandak J, Djali S. Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin. Neurochemistry International. March 2002, 40 (3): 203–9. PMID 11741003. S2CID 24104458. doi:10.1016/S0197-0186(01)00082-1.
