內輸蛋白亞基α-2

位於17號人類染色體的基因

內輸蛋白亞基α-2(英語:Importin subunit alpha-2)是人體內的一種蛋白質,為內輸蛋白α英語Importin α的一種,由17號染色體上的KPNA2基因編碼。[5][6]

內輸蛋白亞基α-2
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名KPNA2;, IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58
外部IDOMIM600685 MGI103561 HomoloGene1708 GeneCardsKPNA2
基因位置(人類
17號染色體
染色體17號染色體[1]
17號染色體
內輸蛋白亞基α-2的基因位置
內輸蛋白亞基α-2的基因位置
基因座17q24.2起始68,035,636 bp[1]
終止68,047,364 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_002266
​NM_001320611

NM_010655

蛋白序列

NP_001307540
​NP_002257

NP_034785

基因位置​(UCSC)Chr 17: 68.04 – 68.05 MbChr 11: 106.88 – 106.89 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能

編輯

內輸蛋白亞基α-2參與了蛋白質由細胞質轉運進細胞核的過程,細胞質中,內輸蛋白α可結合具有核定位序列的蛋白質[7],接著再與內輸蛋白β結合而形成二聚體,後者可與核孔複合物互動,使二聚體和蛋白質一起進入細胞核中。入核後,內輸蛋白二聚體與Ran-GTP結合而將原本結合的蛋白質釋出,再回到細胞質中。此過程與Ran循環英語Ran (protein)偶連,並需消耗能量[8]

除了協助蛋白質進入細胞核外,KPNA2可能也參與V(D)J重組英語V(D)J recombination[9]

交互作用

編輯

核轉運蛋白α-2會與以下的蛋白質產生交互作用

參考文獻

編輯
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000182481 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proceedings of the National Academy of Sciences of the United States of America. Jun 1994, 91 (13): 6156–60. PMC 44157 . PMID 8016130. doi:10.1073/pnas.91.13.6156. 
  6. ^ Weis K, Mattaj IW, Lamond AI. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science. May 1995, 268 (5213): 1049–53. PMID 7754385. doi:10.1126/science.7754385. 
  7. ^ Moroianu, J; Blobel, G; Radu, A. Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.. Proceedings of the National Academy of Sciences of the United States of America. 1995-03-14, 92 (6): 2008–2011. ISSN 0027-8424. PMC 42412 . PMID 7892216. doi:10.1073/pnas.92.6.2008. 
  8. ^ Goldfarb, David S.; Corbett, Anita H.; Mason, D. Adam; Harreman, Michelle T.; Adam, Stephen A. Importin α: a multipurpose nuclear-transport receptor. Trends in Cell Biology. 2004, 14 (9): 505–514. PMID 15350979. doi:10.1016/j.tcb.2004.07.016. 
  9. ^ Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1). (原始內容存檔於2010-12-05). 
  10. ^ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. The Journal of Biological Chemistry. Dec 2000, 275 (48): 37815–23. PMID 10980193. doi:10.1074/jbc.M002470200. 
  11. ^ Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha). International Immunology. Oct 2001, 13 (10): 1265–74. PMID 11581171. doi:10.1093/intimm/13.10.1265. 
  12. ^ Nagoshi E, Yoneda Y. Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta. Molecular and Cellular Biology. Apr 2001, 21 (8): 2779–89. PMC 86908 . PMID 11283257. doi:10.1128/MCB.21.8.2779-2789.2001. 
  13. ^ Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Molecular and Cellular Biology. Nov 1999, 19 (11): 7782–91. PMC 84838 . PMID 10523667. doi:10.1128/mcb.19.11.7782. 
  14. ^ Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell. Sep 1997, 90 (6): 1061–71. PMID 9323134. doi:10.1016/s0092-8674(00)80372-4. 
  15. ^ Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML. Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. The Journal of Biological Chemistry. May 2002, 277 (22): 19673–8. PMID 11882654. doi:10.1074/jbc.M112112200. 
  16. ^ Seki T, Tada S, Katada T, Enomoto T. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochemical and Biophysical Research Communications. May 1997, 234 (1): 48–53. PMID 9168958. doi:10.1006/bbrc.1997.6535. 
  17. ^ Maiyar AC, Leong ML, Firestone GL. Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Molecular Biology of the Cell. Mar 2003, 14 (3): 1221–39. PMC 151592 . PMID 12631736. doi:10.1091/mbc.E02-03-0170. 

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