內輸蛋白亞基α-2
位於17號人類染色體的基因
內輸蛋白亞基α-2(英語:Importin subunit alpha-2)是人體內的一種蛋白質,為內輸蛋白α的一種,由17號染色體上的KPNA2基因編碼。[5][6]
功能
编辑內輸蛋白亞基α-2參與了蛋白質由細胞質轉運進細胞核的過程,細胞質中,內輸蛋白α可結合具有核定位序列的蛋白質[7],接著再與內輸蛋白β結合而形成二聚體,後者可與核孔複合物互動,使二聚體和蛋白質一起進入細胞核中。入核後,內輸蛋白二聚體與Ran-GTP結合而將原本結合的蛋白質釋出,再回到細胞質中。此過程與Ran循環偶連,並需消耗能量[8]。
交互作用
编辑核轉運蛋白α-2會與以下的蛋白質產生交互作用:
參考文獻
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- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000018362 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1). (原始内容存档于2010-12-05).
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延伸閱讀
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