周期蛋白D1

周期蛋白D1
周期蛋白D1
	Rendering based on PDB 2W96.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	2W96, 2W99, 2W9F, 2W9Z
標識
代號	CCND1; BCL1; D11S287E; PRAD1; U21B31
擴展標識	遺傳學：168461 鼠基因：88313 同源基因：1334 ChEMBL: 3610 GeneCards: CCND1 Gene
基因本體論描述
分子功能	· protein kinase activity; · protein binding; · cyclin-dependent protein serine/threonine kinase regulator activity; · enzyme binding; · protein kinase binding; · protein complex binding;
細胞成分	· cyclin-dependent protein kinase holoenzyme complex; · intracellular; · nucleus; · nucleoplasm; · cytosol; · tight junction; · membrane;
生物過程	· G1 phase of mitotic cell cycle; · G1/S transition of mitotic cell cycle; · S phase of mitotic cell cycle; · mitotic cell cycle; · re-entry into mitotic cell cycle; · liver development; · positive regulation of protein phosphorylation; · response to DNA damage stimulus; · lactation; · response to iron ion; · response to X-ray; · response to organic nitrogen; · negative regulation of Wnt receptor signaling pathway; · negative regulation of epithelial cell differentiation; · endoplasmic reticulum unfolded protein response; · organ regeneration; · mitotic G1 DNA damage checkpoint; · response to magnesium ion; · response to vitamin E; · Leydig cell differentiation; · mammary gland epithelial cell proliferation; · positive regulation of mammary gland epithelial cell proliferation; · response to drug; · response to estrogen stimulus; · fat cell differentiation; · response to ethanol; · positive regulation of cyclin-dependent protein kinase activity; · cell division; · response to corticosterone stimulus; · response to calcium ion; · canonical Wnt receptor signaling pathway; · mammary gland alveolus development; · response to UV-A; · regulation of G1/S transition of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	595
Ensembl	ENSG00000110092
UniProt	P24385
mRNA序列	NM_053056
蛋白序列	NP_444284
基因位置	Chr 11:; 69.46 – 69.47 Mb
PubMed查詢	[1]
	閱; 論; 編;

G1/S-特異性周期蛋白-D1是一個由人類CCND1基因所編碼的蛋白質^[1]^[2]。

該基因編碼的蛋白質屬於高度保守的周期蛋白家族，該家族成員的顯著特徵是貫穿細胞周期，其蛋白質豐度周期性地急劇改變。周期蛋白作為CDK（周期蛋白依賴性激酶）的調節因子。不同的周期蛋白表現出各自獨特的表達及降解特性，這有助於每個有絲分裂事件在時間上的協調性。周期蛋白D1這種亞型的周期蛋白與CDK4或CDK6形成複合物並作為它們的調節亞基，這兩種周期蛋白依賴性激酶對於G₁到S期的轉變來說是不可或缺的。該蛋白表現出與抑癌基因Rb有著相互作用，且此基因的表達受Rb的正向調控。周期蛋白D1發生突變、擴增及過表達將會改變細胞周期進程，這些現象常發生在多種腫瘤中並可能導致腫瘤發生^[3]。

使用周期蛋白D1進行免疫組化染色可用於診斷套細胞淋巴瘤。

另見

參考文獻

^ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.
^ Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.
^ Entrez Gene: CCND1 cyclin D1. （原始內容存檔於2009-05-11）.

深入閱讀

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[pmid1826542-1] Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.

[pmid1833066-2] Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.

[entrez-3] Entrez Gene: CCND1 cyclin D1. （原始內容存檔於2009-05-11）.

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