1-(2-聯苯基)哌嗪
化合物
1-(2-聯苯基)哌嗪是一種有機化合物，化學式為C16H18N2。它可由1-叔丁氧羰基-4-(2-溴苯基)哌嗪和苯硼酸在四(三苯基膦)鈀催化下反應製得，[1]或由2-氨基聯苯和二(氯乙基)胺鹽酸鹽在碳酸鉀和碘化鉀存在下反應得到。[2]它和N-苄基-6-溴己醯胺在碳酸鉀存在下於乙腈中回流反應，可以得到N-苄基-(4-聯苯-2-基)哌嗪己醯胺。[3]
piperazine.svg) | |
| 識別資訊 | |
|---|---|
| |
| CAS號 | 180698-18-4  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化學資訊 | |
| 化學式 | C16H18N2 |
| 摩爾質量 | 238.33 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
參考文獻
編輯- ^ Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.
- ^ Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始內容存檔於2022-03-05） （英語）.
- ^ Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始內容存檔於2022-03-05） （英語）.