R13 (藥物)

化合物

R13是一種小分子黃酮類化合物藥物,可口服給藥[1],是腦源性神經營養因子受體——Trk受體B(TrkB)的選擇性激動劑,用於阿茲海默症的治療[2]

R13
臨床資料
其他名稱4-Oxo-2-phenyl-4H-chromene-7,8-diyl bis(methylcarbamate)
給藥途徑口服給藥[1]
藥物動力學數據
代謝產物7,8-二羥基黃酮[1]
識別資訊
  • [8-(Methylcarbamoyloxy)-4-oxo-2-phenylchromen-7-yl] N-methylcarbamate
CAS號1609067-49-3  checkY
PubChem CID
UNII
化學資訊
化學式C19H16N2O6
摩爾質量368.35 g·mol−1
3D模型(JSmol英語JSmol
  • CNC(=O)OC1=C(C2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3)OC(=O)NC
  • InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24)
  • Key:NWWRHMSYZTWUBD-UHFFFAOYSA-N

參考文獻

編輯
  1. ^ 1.0 1.1 1.2 Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K. The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. January 2018, 115 (3): 578–583. PMC 5777001 . PMID 29295929. doi:10.1073/pnas.1718683115 . 
  2. ^ US application 20150274692,Keqiang Ye,「7,8-Dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto」,發表於2015-10-01,指定於Emory University 

外部連結

編輯